Results 71 to 80 of about 1,159,139 (296)

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Calcineurin Subunits A and B Interact to Regulate Growth and Asexual and Sexual Development in Neurospora crassa. [PDF]

PLoS ONE, 2016
Calcineurin is a calcium/calmodulin dependent protein phosphatase in eukaryotes that consists of a catalytic subunit A and a regulatory subunit B. Previous studies in the filamentous fungus Neurospora crassa had suggested that the catalytic subunit of ...
Ranjan Tamuli, Rekha Deka, Katherine A Borkovich   +2 more
doaj   +1 more source

Repetitive Segmental Structure of the Transducin β Subunit: Homology with the CDC4 Gene and Identification of Related mRNAs [PDF]

, 1986
Retinal transducin, a guanine nucleotide regulatory protein (referred to as a G protein) that activates a cGMP phosphodiesterase in photoreceptor cells, is comprised of three subunits.
Doolittle, Russell F., Fong, Henry K. W., Hopkins, Rosemary S., Hurley, James B., Johnson, Mark S., Miake-Lye, Ryn, Simon, Melvin I.   +6 more
core  

Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation [PDF]

, 2008
Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor ...
Berman, C.-K. Chen, Chan, Chen, Chen, Chen, Coleman, De Vries, Grafstein-Dunn, He, Heximer, K. C. Slep, Kimple, Koelle, Kozasa, Kozasa, Kudlacek, Lodowski, M. A. Kercher, M. I. Simon, McIntire, Neubig, Noel, P. B. Sigler, Slep, Snow, Sondek, Sunahara, T. Wieland, Tesmer, Tesmer, Valenzuela, Wang, Wilkie, Willars   +34 more
core   +4 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

The regulatory subunit MoB56 of PP2A phosphatase regulates pathogenicity, growth and development in a protein complex with the atypical catalytic subunit Ppg1 in the rice blast fungus Magnaporthe oryzae

Phytopathology Research, 2023
Protein phosphatase 2A (PP2A) is usually a heterotrimeric enzyme, consisting of a catalytic subunit (C) and a scaffolding subunit (A) associated with a third, variable regulatory subunit (B).
Rui-Jin Wang, Danrui Cui, Rui Zhao, Yujie Jin, Wenhui Zeng, Ye Yang, Linlu Qi, Lihui Xiang, You-Liang Peng   +8 more
doaj   +1 more source

The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex [PDF]

, 2013
The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia.
A Sisto, AE Lang, C Gatsogiannis, C McNulty, CP Silva, D Bowen, D Liu, D Zhang, DL Erickson, EF Boyd, Frederick M. Ausubel, G Yang, Guowei Yang, H Gotoh, H Li, I Gendlina, J Soding, JJ Sheets, M Blackburn, M Blackburn, M Sergeant, MC Hares, MJ Landsberg, MR Hurst, N Waterfield, N Waterfield, Nicholas R. Waterfield, NR Waterfield, NR Waterfield, NR Waterfield, R Ffrench-Constant, R Zhao, SC Lee, SK Aoki, SM Tennant, VL Kung, YD Wang, ZC Ruhe   +37 more
core   +3 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Ribosomal history reveals origins of modern protein synthesis. [PDF]

PLoS ONE, 2012
The origin and evolution of the ribosome is central to our understanding of the cellular world. Most hypotheses posit that the ribosome originated in the peptidyl transferase center of the large ribosomal subunit.
Ajith Harish, Gustavo Caetano-Anollés
doaj   +1 more source

Intramitochondrial sorting of the precursor to yeast cytochrome c oxidase subunit Va. [PDF]

, 1993
We have continued our studies on the import pathway of the precursor to yeast cytochrome c oxidase subunit Va (pVa), a mitochondrial inner membrane protein.
Cumsky, MG, Miller, BR
core