Results 111 to 120 of about 723,818 (342)

Modulation of cardiac Ca2+ channels in Xenopus oocytes by protein kinase C [PDF]

, 1992
L-Type calcium channel was expressed in Xenopus laevis oocytes injected with RNAs coding for different cardiac Cu2+ channel subunits, or with total heart RNA.
Biel, Biel, Bosse, Bourinet, Catterall, Catterall, Chang, Chang, Chang, Dafna Singer-Lahat, Dascal, Dascal, Dascal, Dascal, Dascal, Dosemeci, Eli Gershon, Ellis, Fenwick, Franz Hofmann, Glossmann, Gutierrez, Guy, Hofmann, Hullin, Ilana Lotan, Itagaki, Jay, Lacerda, Lory, Lotan, Martin Biel, Mikami, Mori, Morton, Nastainczyk, Nathan Dascal, O'Callahan, O'Callahan, Perez-Reyes, Perez-Reyes, Reuter, Roger Hullin, Ruth, Shearman, Sieber, Singer, Tanabe, Trautwein, Tseng, Tsien, Varadi, Vasilets, Veit Flockerzi, Williams   +54 more
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Comparing the Effect of Ionizing Radiations of Electron Beam and Gamma Ray on Ruminal Degradation Kinetics of Soybean Meal Protein and Amino acids

پژوهشهای علوم دامی ایران, 2014
This research was conducted to compare effects of electron beam (EB) and gamma ray (GR) treatments at doses of 25, 50 and 75 kGy on soybean meal (SBM) ruminal degradation kinetics of crude protein (CP) and amino acids (AA).
Farzad Ghanbari, T. Ghoorchi, Parvin Shawrang, Noor-Mohammad Torbatinejad   +3 more
doaj  

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits. [PDF]

Mol Cell, 2023
Park JC, Luebbers A, Dao M, Semeano A, Nguyen AM, Papakonstantinou MP, Broselid S, Yano H, Martemyanov KA, Garcia-Marcos M.   +9 more
europepmc   +1 more source

Amyloid. 3. A protein related to the subunit structure of human amyloid fibrils. [PDF]

, 1966
Earl P. Benditt, Nils Eriksen
openalex   +1 more source

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Akaike, N, Ha, SH, Hirata, M, Jang, IS, Jovanovic, JN, Kanematsu, T, Kittler, JT, Moss, SJ, Nakayama, KI, Ryu, SH, Terunuma, M   +10 more
core  

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Single-Nucleotide Polymorphism in Genes Encoding G Protein Subunits GNB3 and GNAQ Increase the Risk of Cardiovascular Morbidity among Patients Undergoing Renal Replacement Therapy. [PDF]

Int J Mol Sci, 2023
Birkner S, Möhlendick B, Wilde B, Schoenfelder K, Boss K, Siffert W, Kribben A, Friebus-Kardash J.   +7 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Agonist-Dependent Coupling of the Promiscuous Adenosine A_2B Receptor to Gα Protein Subunits. [PDF]

ACS Pharmacol Transl Sci, 2022
Voss JH, Mahardhika AB, Inoue A, Müller CE.   +3 more
europepmc   +1 more source