Results 111 to 120 of about 708,409 (312)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Diversity of heterotrimeric G-protein γ subunits in plants

BMC Research Notes, 2012
Background Heterotrimeric G-proteins, consisting of three subunits Gα, Gβ and Gγ are present in most eukaryotes and mediate signaling in numerous biological processes.
Trusov Yuri, Chakravorty David, Botella José   +2 more
doaj   +1 more source

Structural and Functional Properties of the H and M Subunits of Lactic Dehydrogenases [PDF]

Structural and functional properties of H and M protein subunits of lactic ...
Fondy, T. P., Kaplan, N. O.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparing the Effect of Ionizing Radiations of Electron Beam and Gamma Ray on Ruminal Degradation Kinetics of Soybean Meal Protein and Amino acids

پژوهشهای علوم دامی ایران, 2014
This research was conducted to compare effects of electron beam (EB) and gamma ray (GR) treatments at doses of 25, 50 and 75 kGy on soybean meal (SBM) ruminal degradation kinetics of crude protein (CP) and amino acids (AA).
Farzad Ghanbari, T. Ghoorchi, Parvin Shawrang, Noor-Mohammad Torbatinejad   +3 more
doaj  

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

A mathematical model of protein subunits COVID-19 vaccines. [PDF]

Math Biosci, 2023
Gholami S, Korosec CS, Farhang-Sardroodi S, Dick DW, Craig M, Ghaemi MS, Ooi HK, Heffernan JM.   +7 more
europepmc   +1 more source

The G Protein Subunit Gene Families

Genomics, 1999
t i t u p g s t ( uch as neurotransmitters, hormones, and light. The vast ajority of such receptors are coupled to G proteins, which ransduce the signal to effectors. G proteins are heterotrimrs made up of an a, a b, and a g subunit (29). The G protein ubunits are now known to be encoded by families of related enes in mammalian cells (74). The sizes of
G B, Downes, N, Gautam
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits. [PDF]

Mol Cell, 2023
Park JC, Luebbers A, Dao M, Semeano A, Nguyen AM, Papakonstantinou MP, Broselid S, Yano H, Martemyanov KA, Garcia-Marcos M.   +9 more
europepmc   +1 more source