Results 281 to 290 of about 723,610 (311)

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

The cys-loop ligand-gated ion channel gene superfamily of the Colorado potato beetle, Leptinotarsa decemlineata. [PDF]

BMC Genomics
Chen D, Hawthorne DJ.
europepmc   +1 more source

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Heterochannels Kv(1.1-1.2)₂ and Their Interactions with Pore Blockers. [PDF]

Cells
Efremenko AV, Kryukova EV, Kazakov OV, Ignatova AA, Shmatin II, Korabeynikova VN, Toporova VA, Yakimov SA, Kirpichnikov MP, Nekrasova OV, Feofanov AV.   +10 more
europepmc   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

COP9 Signalosome's Role in Plant Defense Mechanisms. [PDF]

Plants (Basel)
Lu Z, Li C, Deng K, Han C, Shan Z, Chen S, Yang H, Yang Y, Chen H, Hao Q.   +9 more
europepmc   +1 more source

Current landscape of the immunoproteasome: implications for disease and therapy. [PDF]

Cell Death Discov
Zou Z, Hao Y, Tao Z, Ye W, Luo Z, Li X, Li R, Zheng K, Xia J, Guo C, Zhang X, Wu J.   +11 more
europepmc   +1 more source

DNA-bound structure of Clostridioides difficile heme-sensing HsmR gives insight on how the unique dimer mode governs DNA specificity in MarR transcriptional regulators. [PDF]

Nucleic Acids Res
Rho S, Kwon N, Park S.
europepmc   +1 more source

Composition and RNA binding specificity of metazoan RNase MRP. [PDF]

Nucleic Acids Res
Liu Y, He S, Pyo K, Zheng S, Chen M, Braschi B, Cheloufi S, Slavov N, Marzluff WF, Murn J.   +9 more
europepmc   +1 more source

Evolution and structural diversity of the MotAB stator: insights into the origins of bacterial flagellar motility. [PDF]

mBio
Puente-Lelievre C, Ridone P, Douglas J, Amritkar K, Kaçar B, Baker MAB, Matzke NJ.   +6 more
europepmc   +1 more source