Results 71 to 80 of about 711,796 (313)

Modulation of the mitochondrial Ca2+ uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells

Physiological Reports, 2023
Mitochondrial calcium (mCa2+) uptake occurs via the Mitochondrial Ca2+ Uniporter (MCU) complex and plays a critical role in mitochondrial dynamics, mitophagy, and apoptosis.
Akshar Patel, Julia G. Pietromicca, Manigandan Venkatesan, Soumya Maity, Jonathan E. Bard, Muniswamy Madesh, B. Rita Alevriadou   +6 more
doaj   +1 more source

Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]

, 2012
Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter, Kötter, Peter, Lamberth, Stefanie, Peifer, Christian, Sharma, Sunny, Watzinger, Peter   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

EVOLUTION OF PROTEIN COMPLEXES IN BACTERIAL SPECIES [PDF]

, 2017
Protein complexes are composed of two or more associated polypeptide chains that may have different functions. Protein complexes play a critical role for all processes in life and are considered as highly conserved in evolution.
Albalawi, Wedad, Sridhar, Shwetha Hara, Uetz, Peter   +2 more
core   +1 more source

Mechanical response of random heteropolymers [PDF]

, 2001
We present an analytical theory for heteropolymer deformation, as exemplified experimentally by stretching of single protein molecules. Using a mean-field replica theory, we determine phase diagrams for stress-induced unfolding of typical random ...
Best R., Binder K., Crooks G. E., Derrida B., Derrida B., Dill K. A., Geissler P. L., Grosberg A., Halperin A., Hummer G., Jarzynski C., Kantor Y., Klimov D. K., Klimov D. K., Li H., Marenduzzo D., Marszalek P. E., Mezard M., Oberhauser A. F., Paci E., Sfatos C. D., Shakhnovich E. I., Socci N. D., Tamashiro M. N., Vilgis T. A., Xiao L., Yang G.   +26 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Subunit interactions of the Go protein

FEBS Letters, 1992
The monoclonal antibody, MONO, recognizes an epitope on the G protein αo‐subunit [van der Voorn et al., submitted] and readily immunoprecipitates heterotrimeric Go proteins from solubilized, crude bovine brain membranes, as well as from a purified bovine brain G protein preparation.
van der Voorn, Loesje, Hengeveld, Trudi M., Ploegh, Hidde L.   +2 more
openaire   +2 more sources

Protein subunit interfaces: heterodimers versus homodimers [PDF]

Bioinformation, 2005
Protein dimers are either homodimers (complexation of identical monomers) or heterodimers (complexation of non-identical monomers). These dimers are common in catalysis and regulation. However, the molecular principles of protein dimer interactions are difficult to understand mainly due to the geometrical and chemical characteristics of proteins ...
Cui, Zhanhua, Jacob Gah-Kok, Gan, Li, Lei, Meena Kishore, Sakharkar, Pandjassarame, Kangueane   +4 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit

Journal of Integrative Neuroscience, 2019
The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain.
Furkan Enes Oflaz, Çağdaş Devrim Son, Ayla Arslan   +2 more
doaj   +1 more source