Results 111 to 120 of about 1,784,597 (218)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis. [PDF]

Nat Commun
Sarrazin L, Rosenthal MR, Kloehn J, Ziesmann T, Schmitz Y, Sandtmann AL, Domènech-Eres R, Scholz-Höhn K, Boulet C, Distler U, Goldberg DE, Matz JM.   +11 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Retraction Note: α-Ketoglutarate dictates AMPK protein synthesis for energy sensing in human cancers. [PDF]

Nat Chem Biol
Mi W, Xue Y, Yan H, Zhang Y, Cai X, Zhang S, He R, Li L, Zhu L, Xia X, Liang Y, Cao C, Xu Y, Bi J, Wang G, Chen L, Dan Ye, Li F, Ren R, Liu P, Ji H, Li F.   +21 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Glutathione-Responsive Acyl-Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis. [PDF]

Angew Chem Int Ed Engl
Flood ME, Kurusamy S, Berney M, Smales CM, Topp EM, McGouran JF, Ferguson S.   +6 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling. [PDF]

Cell Metab
Adler D, Martín-Ávila A, Cheng E, Oliveira MM, Zhang M, Evans HT, Yuan D, Sam R, Zhang ND, Selles MC, Mosto O, Liu WJ, Wu VT, Guo AX, Liddelow SA, Froemke RC, Chao MV, Gan WB, Klann E.   +18 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes. [PDF]

J Physiol
Sandmann C, Brandenburg S, Uhlenkamp D, Meyer B, Sandmann C, Herzog N, Groß J, Funaya C, Katus HA, Lehnart SE, Glembotski CC, Völkers M, Doroudgar S.   +12 more
europepmc   +1 more source