Results 151 to 160 of about 7,364,139 (305)

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis. [PDF]

Nat Commun
Sarrazin L, Rosenthal MR, Kloehn J, Ziesmann T, Schmitz Y, Sandtmann AL, Domènech-Eres R, Scholz-Höhn K, Boulet C, Distler U, Goldberg DE, Matz JM.   +11 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Impact of Reducing Agents on Protein Synthesis in a Reconstituted Cell-Free Protein Synthesis System. [PDF]

ACS Synth Biol
Fuse-Murakami T, Terazawa S, Gondhalekar R, Ito S, Miyawaki S, Mizukami Y, Salgado WP, Yang Z, Fujishima K, Kanamori T.   +9 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling. [PDF]

Cell Metab
Adler D, Martín-Ávila A, Cheng E, Oliveira MM, Zhang M, Evans HT, Yuan D, Sam R, Zhang ND, Selles MC, Mosto O, Liu WJ, Wu VT, Guo AX, Liddelow SA, Froemke RC, Chao MV, Gan WB, Klann E.   +18 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes. [PDF]

J Physiol
Sandmann C, Brandenburg S, Uhlenkamp D, Meyer B, Sandmann C, Herzog N, Groß J, Funaya C, Katus HA, Lehnart SE, Glembotski CC, Völkers M, Doroudgar S.   +12 more
europepmc   +1 more source

Chemical protein synthesis [PDF]

Journal of Peptide Science, 2014
Christian F W, Becker, Ashraf, Brik, Phil, Dawson, Christian P R, Hackenberger   +3 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis. [PDF]

Sci Adv
Buchanan CN, Lee J, Matoo S, Headen JA, Honoree MC, Conway M, Thompson LF, Smith TP, McKay A, Tosadori C, Dalla Costa I, Lopez De Leon M, Thames E, Perrone-Bizzozero N, Kalinski AL, Welshhans K, Vaughn LS, Twiss JL.   +17 more
europepmc   +1 more source