Results 281 to 290 of about 11,322,924 (398)

Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth. [PDF]

Nat Commun
Maekiniemi A, Savakis P, van Rossum K, Snoep JL, Seiler M, van Niekerk DD, Zarnack K, Singer RH, Tutucci E.   +8 more
europepmc   +1 more source

Global analysis of protein folding using massively parallel design, synthesis, and testing

Science, 2017
G. Rocklin, T. M. Chidyausiku, Inna Goreshnik, Alex Ford, S. Houliston, A. Lemak, L. Carter, Rashmi Ravichandran, V. Mulligan, A. Chevalier, C. Arrowsmith, D. Baker   +11 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Coordinated regulation of protein synthesis and degradation by mTORC1

Nature, 2014
Yinan Zhang, Justin W. Nicholatos, John R. Dreier, S. Ricoult, Scott B. Widenmaier, G. Hotamışlıgil, D. Kwiatkowski, B. Manning   +7 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Correction for Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration. [PDF]

Mol Biol Cell
europepmc   +1 more source

Rapid vinyl thianthrenium tetrafluoroborate-promoted thioacid-based native chemical ligation and its applications in chemical protein synthesis. [PDF]

Commun Chem
Li H, Xu S, Zhang Z, Xie R, Liu J, Ma J, Zheng C, Chen C, Chen W, Liu J.   +9 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Azidohomoalanine (AHA) Metabolic Labeling Reveals Unique Proteomic Insights into Protein Synthesis and Degradation in Response to Bortezomib Treatment. [PDF]

Proteomes
Alhourani L, Tabana Y, Anand A, Fahlman RP.   +3 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source