Results 71 to 80 of about 7,364,139 (305)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Oxygen-tolerant, Eosin Y mediated synthesis of protein-polymer biohybrids and protein-coated polymer nanoparticles [PDF]

To avoid the use of metal catalysts used in conventional approaches, an Eosin Y/TEMED mediated, photoinduced polymerization of vinyl monomers was optimized for the synthesis of protein-polymer conjugates.
Errika , Voutyritsa, Thomai, Lazou, Myrto, Charitaki, Stavroula, Margaritaki, Nikos , Hatzakis, Sune M. , Christensen, Jonida, Bushi, Kelly, Velonia   +7 more
core   +2 more sources

Autophagy under glucose starvation enhances protein translation initiation in response to re‐addition of glucose in C2C12 myotubes

FEBS Open Bio, 2020
Proteolysis is known to play a crucial role in maintaining skeletal muscle mass and function. Autophagy is a conserved intracellular process for the bulk degradation of proteins in lysosomes. Although nutrient starvation is known to induce autophagy, the
Naoya Nakai, Saki Kitai, Noriko Iida, Sachika Inoue, Kazuhiko Higashida   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Mechanisms of the development of skeletal muscle atrophy in chronic alcohol intoxication

Анналы клинической и экспериментальной неврологии, 2017
Chronic alcohol myopathy (CAM) is one of frequent manifestationsof the alcoholic disease, but its pathogenesis remains to be elucidated.Main mechanism of the CAM development is suggested tobe abnormalities of protein synthesis in muscle fibers.
Yu. V. Kazantseva, G. V. Maslova, E. A. Lysenko, O. E. Zinovyeva, B. S. Shenkman, N. N. Yakhno   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Investigating Synthesis of the MalS Malic Enzyme during Bacillus subtilis Spore Germination and Outgrowth and the Influence of Spore Maturation and Sporulation Conditions

mSphere, 2020
Spore-forming bacteria of the orders Bacillales and Clostridiales play a major role in food spoilage and foodborne diseases. When environmental conditions become favorable, these spores can germinate as the germinant receptors located on the spore’s ...
Bhagyashree Swarge, Chahida Nafid, Norbert Vischer, Gertjan Kramer, Peter Setlow, Stanley Brul   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis [PDF]

, 2013
Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual ...
Bohne, Alexandra-Viola, Marco Schottkowski, Michael Lidschreiber, Zerges, William, Markus Piotrowski (169373), Markus Piotrowski, Michael Lidschreiber (138963), Christian Schwarz, Alexandra-Viola Bohne (281295), Marco Schottkowski (281297), William Zerges, Nickelsen, Jörg, Jörg Nickelsen (13576), Piotrowski, Markus, Alexandra-Viola Bohne, Christian Schwarz (281296), Lidschreiber, Michael, Jörg Nickelsen, Schottkowski, Marco, Schwarz, Christian, William Zerges (95563)   +20 more
core   +1 more source

The Regulation of Muscle Mass by Endogenous Glucocorticoids

Frontiers in Physiology, 2015
Glucocorticoids are highly conserved fundamental regulators of energy homeostasis. In response to stress in the form of perceived danger or acute inflammation, glucocorticoids are released from the adrenal gland, rapidly mobilizing energy from ...
Daniel L Marks, Theodore P. Braun
doaj   +1 more source