Results 121 to 130 of about 3,768,680 (342)

Targeting protein lipidation in disease [PDF]

Trends in Molecular Medicine, 2012
Fatty acids and/or isoprenoids are covalently attached to a variety of disease-related proteins. The distinct chemical properties of each of these hydrophobic moieties allow lipid modification to serve as a mechanism to regulate protein structure, localization and function.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

AtPex14p maintains peroxisomal functions by determining protein targeting to three kinds of plant peroxisomes [PDF]

, 2000
Makoto Hayashi
openalex   +1 more source

Path separation of dissipation-corrected targeted molecular dynamics simulations of protein-ligand unbinding [PDF]

, 2022
Steffen Wolf, Matthias Post, Gerhard Stock   +2 more
openalex   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Corrigendum: Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses

Frontiers in Immunology, 2022
Bo-Seong Jeong, Joon Young Jeon, Chih-Jen Lai, Hye-Yeoung Yun, Jae U. Jung, Byung-Ha Oh, Byung-Ha Oh   +6 more
doaj   +1 more source

Cytotoxic G-rich oligodeoxynucleotides: putative protein targets and required sequence motif [PDF]

, 2007
Amber Goodchild, Andrew King, Mary Margaret G. Gozar, Toby Passioura, Carly Tucker, Laurent P. Rivory   +5 more
openalex   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Stretching Peptides’ Potential to Target Protein–Protein Interactions

ACS Central Science, 2023
Naresh M. Venneti, Jennifer L. Stockdill
doaj   +1 more source

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source