Results 141 to 150 of about 3,768,680 (342)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Protein-Protein Interaction Analysis Reveals A Novel Cancer Stem Cell Related Target TMEM17 in Colorectal Cancer [PDF]

, 2020
Zhaoliang Yu, Yufeng Chen, Bin Zheng, Zerong Cai, Yifeng Zou, Jia Ke, Ping Lan, Feng Gao, Xiaojian Wu   +8 more
openalex   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex

Life Science Alliance
The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis. KRAS is a proto-oncogene encoding a small GTPase.
Andreas Damianou, Zhu Liang, Frederik Lassen, Iolanda Vendrell, George Vere, Svenja Hester, Philip D Charles, Adan Pinto-Fernandez, Alberto Santos, Roman Fischer, Benedikt M Kessler   +10 more
doaj   +1 more source

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2. [PDF]

Front Immunol, 2023
Kaur P, Dey A, Rawat K, Dey S.
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Deep generative model for drug design from protein target sequence. [PDF]

J Cheminform, 2023
Chen Y, Wang Z, Wang L, Wang J, Li P, Cao D, Zeng X, Ye X, Sakurai T.   +8 more
europepmc   +1 more source

Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly [PDF]

, 2013
Lauren A. Solomon, Bailey A. Russell, L. Ashley Watson, Frank Beier, Nathalie G. Bérubé   +4 more
openalex   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

AlphaDrug: protein target specific de novo molecular generation. [PDF]

PNAS Nexus, 2022
Qian H, Lin C, Zhao D, Tu S, Xu L.
europepmc   +1 more source