Results 291 to 300 of about 13,924,024 (337)

Solvent-induced protein precipitation for drug target discovery on proteomic scale.

Analytical Chemistry, 2019
High-throughput drug discovery is highly depended on the targets available to accelerate the process of candidates screening. Traditional chemical proteomics approaches for the screening of drug targets usually require the immobilization/modification of ...
Xiaolei Zhang, Qi Wang, Yanan Li, Chengfei Ruan, Shuyue Wang, Lianghai Hu, M. Ye   +6 more
semanticscholar   +1 more source

Protein–Protein Interactions as Drug Targets

Future Medicinal Chemistry, 2015
Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata, Ottmann, Christian   +1 more
openaire   +2 more sources

Proteolysis-targeting Chimeras for Targeting Protein for Degradation

Future Medicinal Chemistry, 2019
Proteolysis-targeting chimeras (PROTACs) are an emerging tool for therapeutic intervention by reducing or eliminating disease-causing proteins. PROTACs are bifunctional molecules that consist of a target protein ligand, a linker and an E3 ligase ligand, which mediate the polyubiquitination of the target protein, ultimately leading to the target protein
Jianguo, Qi, Gang, Zhang
openaire   +2 more sources

SnapShot: Targeted protein degradation

Cell
Targeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate a protein of interest. Emerging technologies are opening avenues in drug discovery and functional characterization of intracellular, membrane, and extracellular proteins. To view this SnapShot, open or download the PDF.
Yu, Ding, Boxun, Lu
openaire   +2 more sources

Protein Targeting

1996
Abstract Protein targeting is the study of how proteins synthesized in one part of the cell reach their ultimate destination. A cell may have to guide a protein through several membranes into one of its organelles, or take up or secrete a protein through its cell wall. This book is a preview of the latest research in this area, which has
openaire   +1 more source

Protein Targeting

1992
Abstract It has been known for many years that the subcellular distribution of proteins throughout eukaryotic cells is highly ordered. This means that proteins have to be transported to their correct destinations and left there. Understanding the complex mechanisms by which this occurs has provided a major challenge for modern biology ...
openaire   +1 more source

Target Genes: Bone Proteins

2005
http://www.elsevier.com/wps/find/bookdescription.cws_home/703914/description ...
Atkins, G., Findlay, D., Anderson, P., Morris, H.   +3 more
openaire   +3 more sources

Protein Targeting to Yeast Peroxisomes

2007
Peroxisomes are important organelles of eukaryote cells. Although these structures are of relatively small size, they display an unprecedented functional versatility. The principles of their biogenesis and function are strongly conserved from very simple eukaryotes to humans.
van der Klei, Ida, Veenhuis, Marten
openaire   +2 more sources

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

Nature Methods, 2007
Joshua E. Elias, S. Gygi
semanticscholar   +1 more source

Targeting Oncogenic RAS Protein

New England Journal of Medicine, 2022
Dan L, Longo, Neal, Rosen
openaire   +2 more sources