Results 91 to 100 of about 1,760,654 (353)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Characteristic Length Scale of Electric Transport Properties of Genomes

, 2005
A tight-binding model together with a novel statistical method are used to investigate the relation between the sequence-dependent electric transport properties and the sequences of protein-coding regions of complete genomes.
C. T. Shih, D. Holste, S. R. Rajski, W. Li   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy

Frontiers in Immunology
BackgroundTransmembrane emp24 domain-containing protein 2 (TMED2) is involved in the sorting and transport of proteins between the Golgi apparatus and the endoplasmic reticulum.
Zhuangzhi Wang, Zhuangzhi Wang, Changning Sun, Pengfei Wang, Shouyang Lin, Shouyang Lin, Xiao Wu, Yuchao Gu   +7 more
doaj   +1 more source

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

Frontiers in Oncology, 2018
It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in cancer progression.
Tabish Hussain, Jaeho Lee, Martin C. Abba, Junjie Chen, C. Marcelo Aldaz   +4 more
doaj   +1 more source

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia

, 2021
Tooba Quidwai, Jiaolong Wang, Emma A Hall, Narcis A Petriman, Weihua Leng, Petra Kiesel, Jonathan N Wells, Laura C Murphy, Margaret A Keighren, Joseph A Marsh, Esben Lorentzen, Gaia Pigino, Pleasantine Mill   +12 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Molecular Mimicry of SecA and Signal Recognition Particle Binding to the Bacterial Ribosome

mBio, 2019
Bacteria execute a variety of protein transport systems for maintaining the proper composition of their different cellular compartments. The SecYEG translocon serves as primary transport channel and is engaged in transporting two different substrate ...
Lara Knüpffer, Clara Fehrenbach, Kärt Denks, Veronika Erichsen, Narcis-Adrian Petriman, Hans-Georg Koch   +5 more
doaj   +1 more source

Protein dynamics govern the oxyferrous state lifetime of an artificial oxygen transport protein [PDF]

, 2023
Lei Zhang, Mia C. Brown, Andrew C. Mutter, Kelly Greenland, Jason W. Cooley, Ronald L. Koder   +5 more
openalex   +1 more source