HIT101308137 and HIT104293658 nominate dual target chemotypes for PTPN1 and PTPN2 with preliminary selectivity in colorectal cancer cells. [PDF]
Front ChemHuang C, Chen J, Chen R, Cao L.
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Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery. [PDF]
Pharm Sci AdvDu N, Li Y, Lou Q, Zhang G, Li Y, Li Y.
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Proteome-Wide Analysis of Functional Phosphosites in the FGFR Family of Proteins: Insights from Large-Scale Phosphoproteomic Analysis. [PDF]
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ID1 in TAMs promoted the progression of non-small-cell carcinoma via increasing NF-κB/NPM1/SHP1/SHP2 signaling induced M2 polarization. [PDF]
Sci RepJiang P, Chen Z, Cui L, Zhang N, Gao K.
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Genetic Encoding of Pentafluorophosphato-Phenylalanine Provides PF<sub>5</sub>-Proteins as Phosphoprotein Mimetics. [PDF]
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The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia. [PDF]
Int J Mol SciEhm P, Jücker M.
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Regulation and activity of the phosphatase SHP2: SH2 domains, dephosphorylation activity, and beyond. [PDF]
Biochem Soc TransPierotti CL, Köhn M.
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ADAM17, induced by Augmenter of Liver Regeneration via G protein-coupled receptor activation, transactivates epidermal growth factor-receptor and reduces classical IL-6 signaling. [PDF]
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Critical roles of plasma membrane dynamics and heterogeneity at the early stage of antigen-stimulated FcεRI signaling in mast cells. [PDF]
Biochem Soc TransMedda D, Bag N.
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