Cancer signaling networks in tumor progression and drug resistance: Crosstalk, adaptive reprogramming and therapeutic targeting (Review). [PDF]
Li H, Song S, Wang L, Liu Q.
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The Protein Tyrosine Phosphatase 1B Modulates the Activation of Yes-Associated Protein and Sensitizes to Cytotoxic Chemotherapy in Preclinical Models of Cholangiocarcinoma. [PDF]
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Targeting Protein Tyrosine Phosphatases via PROteolysis-TArgeting Chimeras (PROTACs): Current Developments and Prospects. [PDF]
Maccari R.
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Phosphoproteome landscape of ARID1A and its implications in DNA damage response and breast cancer pathogenesis. [PDF]
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Plant Kelch phosphatases are Ser/Thr phosphatases involved in cell cycle regulation
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Non-Receptor Protein Tyrosine Kinases and Phosphatases in Human Platelets
Thrombosis and Haemostasis, 1996There is now a large and rapidly growing body of information on the different types of non-receptor tyrosine kinases and phosphatases present within platelets. These enzymes appear to play a critical role in co-ordinating, integrating and amplifying signals from multiple cell surface receptors.
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Protein tyrosine phosphatase non-receptor type 12 suppresses tumor progression in osteosarcoma cells
Journal of Orthopaedic Science, 2023Protein tyrosine phosphatase non-receptor 12 (PTPN12) plays a prominent role in various cancers as a tumor suppressor. However, the expression of PTPN12 and its biological functions in osteosarcoma (OS) remains to be determined.PTPN12 expression in OS was explored in public databases and detected by immunohistochemistry and Western blot.
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Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia
Gene, 2017The precise origin of Pre-eclampsia (PE) remains elusive. Multiple pieces of evidence support the existence of hypoxia in PE. MiRNA-210 (miR-210), which is induced by Hypoxia-Inducible Factor-1α (HIF-1α) during hypoxia, is one of the most hypoxia sensitive miRNAs. MiR-210 mediates these functions by regulating a lot of target mRNAs.
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