Results 161 to 170 of about 41,275 (256)

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP. [PDF]

Front Med (Lausanne)
Perez-Quintero LA, Abidin BM, Tremblay ML.   +2 more
europepmc   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Protein Tyrosine Phosphatase [PDF]

, 2020
openaire   +1 more source

Identification of broadly expressed nervous system‐related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys

Pest Management Science, EarlyView.
Broadly expressed genes outperformed brain‐enriched neural targets as RNAi candidates in Halyomorpha halys. Microinjection of dsRNA targeting alpha‐soluble NSF attachment protein (Asnap) or Ras opposite protein (Rop) caused strong feeding suppression and near‐complete mortality, identifying them as promising targets for future oral or spray‐based RNAi ...
Nirakar Panda, Aline Koch, Venkata Partha Sarathi Amineni   +2 more
wiley   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Measuring the Reversible Oxidation of Protein Tyrosine Phosphatases Using a Modified Cysteinyl-Labeling Assay. [PDF]

Methods Mol Biol
Londhe AD, Londhe AD, Boivin B.
europepmc   +1 more source

Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates

Small, EarlyView.
De novo designed multidomain peptides (MDPs) were used to explore how molecular ordering influences peptide phase behavior. MDPs containing partially folded β‐sheets were found to form biomolecular condensates. This work introduces a new design principle for condensate formation and expand the design space beyond conventional intrinsically disordered ...
Debdatta Das, Jenny N. Nguyen, Navneet Sahoo, Chuanye Xiong, Haritha Asokan‐Sheeja, Yan Chang, Raniyah Ali, Eleanor D. Smith, Chad A. Brautigam, Yi Hong, Zui Pan, Peng Tao, He Dong   +12 more
wiley   +1 more source

Phosphoproteomics and morphology of stored human red blood cells treated by protein tyrosine phosphatases inhibitor. [PDF]

Blood Adv
Bardyn M, Crettaz D, Rappaz B, Hamelin R, Armand F, Tissot JD, Turcatti G, Prudent M.   +7 more
europepmc   +1 more source

Receptor protein tyrosine phosphatases control Purkinje neuron firing. [PDF]

Cell Cycle, 2020
Brown AS, Meera P, Quinones G, Magri J, Otis TS, Pulst SM, Oro AE.   +6 more
europepmc   +1 more source