Results 101 to 110 of about 510,413 (388)

Successive translocation into and out of the mitochondrial matrix [PDF]

, 1987
We investigated the import and sorting pathways of cytochrome b2 and cytochrome c1, which are functionally located in the intermembrane space of mitochondria.
Alt, Appleby, Bradford, Böhni, Chen, Conboy, Daum, Dowhan, Duffaud, Eilers, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Gubler, Guiard, Hallermayer, Harmey, Hartl, Hartl, Hartl, Hauska, Hay, Hayashi, Horwich, Hurt, Hurt, Hurt, Kaput, Kolanski, Krieg, Laemmli, Lewin, Li, McAda, Miura, Ohashi, Pelham, Perara, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pratje, Riezmann, Rottier, Römisch, Sadler, Schatz, Schleyer, Schleyer, Schmidt, Schmidt, Schwaiger, Simon, Smeekens, Stueber, Talmadge, Teintze, van Loon, van Loon, van Loon, Voordouw, Zimmermann, Zwizinski   +67 more
core   +1 more source

Proteinase-Activated Receptors (PARs), Proteinases and Proteinase Inhibitor Production in Microglial Cells

, 2021
Microglial cells may be seen as a relay station between the periphery and central nervous system (CNS) – they are tasked with modulating signals from the periphery to protect the CNS from potential harm. As such, microglial cells are known as the sentinels of the brain.
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Comparing the frequency, antifungal susceptibility, and enzymatic profiles of the oral fungal composition in patients with and without Alzheimer's disease admitted to a neurology clinic

Frontiers in Cellular and Infection Microbiology
BackgroundStudies have shown that changes in the frequency of oral microorganisms may play a key role in the development of Alzheimer's disease (AD). However, no research has been conducted on the oral fungal composition in AD-patients. The present study
Mandana Golipoor, Zahra Rafat, Alia Saberi, Davoud Roostaei, Amir-Mohammad Shabanpour   +4 more
doaj   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: Implication of Proteinase/Proteinase-Activated Receptor in Gastrointestinal Inflammation

Journal of Pharmacological Sciences, 2008
Recently, the role of serine proteinases in the pathogenesis of inflammation and autoimmune diseases via interaction with the proteinase-activated receptor (PAR) has attracted attention.
Norimasa Yoshida, Toshikazu Yoshikawa
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Antimalarial potential of ethanol extract, and anti-inflammatory properties of flavonoid-, terpenoid-, and alkaloid-rich fractions of Sida linifolia L.

Food Materials Research
Sida linifolia L. has been employed ethnomedicinally in the treatment of inflammatory diseases such as whitlow and malaria but is yet to be scientifically validated for use in the management of ailments.
Nicodemus Emeka Nwankwo, Philip Nwachukwu Ashiakpa   +1 more
doaj   +1 more source

Molecular studies on the sweet potato virus disease and its two causal agents [PDF]

, 2002
The studies presented in this thesis contribute to an increased understanding of the molecular aspects, variability and interaction of the two most important viral pathogens of sweet potato (Ipomoea batatas L): Sweet potato feathery mottle virus (SPFMV ...
Kreuze, Jan
core  

The proteinase: mucus proteinase inhibitor binding stoichiometry.

Journal of Biological Chemistry, 1992
In the nanomolar enzyme and inhibitor concentration range, 1 mol of mucus proteinase inhibitor (MPI) inhibits 1 mol of neutrophil elastase, cathepsin G, trypsin, and chymotrypsin. In the micromolar concentration range, the enzyme:inhibitor binding stoichiometry is still 1:1 for elastase but shifts to 2:1 for the three other proteinases.
C, Boudier, J G, Bieth
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source