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Invivo biosynthesis of vacuolar proteinases in proteinase mutants of Saccharomycescerevisiae
Biochemical and Biophysical Research Communications, 1982Abstract The molecular forms of proteinase A, proteinase B and Car☐ypeptidase Y, enzymes of the lysosome like yeast vacuole, were studied in mutants ( Wolf,D.H. and Fink,G.R. (1975) J. Bacteriol. 123 , 1150–1156 ; Wolf,D.H. and Ehmann,C. (1978) FEBS Lett. 92 , 121–124 ; Mechler,B. and Wolf,D.H. (1981) Eur. J. Biochem.
Hanne Müller +3 more
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Are Proteinases the Reason for Keratoconus?
Current Eye Research, 2010Keratoconus is a degenerating disease of the eye that results in an irregularly-shaped cornea. The etiology of the disease is unknown and the prognosis is difficult due to the variability in outcome. Keratoconus has been associated with eye rubbing, atopy, contact lens wear, as well as genetic conditions, such as Down's syndrome, Ehlers-Danlos syndrome,
David C. Pye +2 more
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Protein Inhibitors of Proteinases
Annual Review of Biochemistry, 1980PERSPECTIVES AND SUMMARY 593 INTRODUCTION 595 Limited Knowledge 0/ Physiological Function 595 Nomenclature Problems 596 0.2 MACROGLOBULINS 598 INHIBITORS WITH CLASS-SPECIFIC REACTIVE SITES 599 Inhibitors 0/ Carboxyl, Metallo and Sulfhydryl Proteinases 599 Inhibitors 0/ Serine Proteinases 601 The Standard Mechanism 601 The nature of ...
M. Laskowski, I Kato
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2002
Publisher Summary This chapter focuses on proteinases in bones, which can be classified into four groups including metalloproteinases, serine proteinases, such as plasminogen activator, cysteine proteinases, and aspartic proteinases. This subdivision is based on the structure and the catalytic mechanism of the active site involving particular amino ...
Stephen M. Krane +3 more
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Publisher Summary This chapter focuses on proteinases in bones, which can be classified into four groups including metalloproteinases, serine proteinases, such as plasminogen activator, cysteine proteinases, and aspartic proteinases. This subdivision is based on the structure and the catalytic mechanism of the active site involving particular amino ...
Stephen M. Krane +3 more
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Proteinases and proteinase inhibitors as modulators of animal cell growth
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19921. Three distinct lines of evidence indicate that proteinases are involved in the growth of cultured animal cells. 2. Endogenous growth-related proteinases have been identified, and exogenous proteinases can also stimulate cell proliferation, probably by different mechanisms. In some cases, higher concentrations of proteinases are cytotoxic.
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Homologies in serine proteinases
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1970Bovine pancreatic juice contains approximately equal amounts of four inactive precursors of endopeptidases (zymogens): chymotrypsinogen A, chymotrypsinogen B, trypsinogen (Keller, Cohen & Neurath 1958) and a component of procarboxypeptidase which resembles a chymotrypsinogen (Brown, Greenshields, Yamasaki & Neurath 1963).
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Proteinases and Proteinase Inhibitors in Human Endometrial Secretion
1985Abstract Human endometrial secretion (ES) had plasminogen activator activity, which was secondary to the presence of both urokinase (UK) and tissue plasminogen activator (t-PA). The activity increased to a maximum in the midcycle phase, was low in the luteal phase, and then rose again premenstrually.
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Characteristics and Functions of Proteinases and Proteinase Inhibitors in Yeast
1976Intracellular proteinases from yeast have been known for long time. By the more recent work of Hata, Hayashi, Lenney and others (for a summery see Holzer et al., 1975) the three proteinases shown in Table 1 have been characterized. The three proteinases are localized in the vacuoles (Matile and Wiemken, 1967).
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