Results 331 to 340 of about 510,413 (388)
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Proteinase-Activated Receptors
Pharmacological Reviews, 2001Proteinase-activated receptors are a recently described, novel family of seven-transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand receptor occupancy, activation is initiated by cleavage of the N terminus of the receptor by a serine protease resulting in the generation of a new tethered ligand that interacts with the ...
S R, Macfarlane +4 more
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Acta Histochemica, 1987
A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
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A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
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Proteinases and Proteinase Inhibitors
1992The peritoneal cavity is well endowed with proteinases both in the parietal and viseral peritoneum as well as in the peritoneal fluid. Proteinases have a major role in activating and modulating the complement, coagulation, kinin, fibrinolytic, and extracellular matrix remodeling systems, and thus are critical components of the peritoneal response to ...
Gere S. diZerega, Kathleen E. Rodgers
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Biochemical Society Transactions, 1992
513 IIIV proteinase is a member of the aspartic I Iurnan immunodeficiency virus (1 IlV), the causative agent of acquired immunodeficiency syndrome (AII)S)9 is a retrovirus. In common with other retroviruses and many other KNA viruses, some of its gene products are expressed in host cells as polyproteins which require subsequent processing by ...
N A, Roberts, J C, Craig, I B, Duncan
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513 IIIV proteinase is a member of the aspartic I Iurnan immunodeficiency virus (1 IlV), the causative agent of acquired immunodeficiency syndrome (AII)S)9 is a retrovirus. In common with other retroviruses and many other KNA viruses, some of its gene products are expressed in host cells as polyproteins which require subsequent processing by ...
N A, Roberts, J C, Craig, I B, Duncan
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Acrosomal Proteinase and Proteinase Inhibitor of Human Spermatozoa
Science, 1972The acrosomal proteinase of human spermatozoa was characterized and differs from other human proteinases. The enzyme has optimal activity at p H 8.0, is inactive below p H 5.0 or above p H 10.5, requires calcium for maximum activity, hydrolyzes fibrinogen, gelatin, and
L J, Zaneveld +2 more
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Proteinase-Protein Inhibitor Interaction
Fibrinolysis, 1991Until recently, the "substrate-like" "canonical" inhibition by the "small" serine proteinase inhibitors, and the product-like inhibition by the carboxypeptidase inhibitor, provided the only models for protein inhibitor-proteinase interactions. The recently published structures of cystatin/stefin-papain complexes and of hirudin-thrombin complexes reveal
W, Bode, R, Huber
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Collagenolytic proteinases in keratoconus
American Journal of Ophthalmology, 2006To study the proteolytic phenomena contributing to the pathogenesis of keratoconus, corneal enzymes with potential to cleave fibrillar collagen were studied.Immunohistochemical labeling was undertaken of conventional and novel mammalian collagenases (MMP-1, -2, -8, -13, and -14) of the matrix metalloproteinase (MMP) family and other collagenolytic ...
Zygmunt, Mackiewicz +5 more
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