Results 161 to 170 of about 194,365 (341)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

The Amino Acid Sequence of Bowman-Birk Soybean Proteinase Inhibitor

, 1971
Shoji Odani, Takehiko Koide, Tokuji Ikenaka   +2 more
openalex   +2 more sources

Immunofluorescent Localization of a Murine Seminal Vesicle Proteinase Inhibitor 1 [PDF]

, 1983
Michael H. Irwin, Nanette Nicholson, John T. Haywood, Gary R. Poirier   +3 more
openalex   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Correction: Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin. [PDF]

PLoS One, 2020
Scott BM, Matochko WL, Gierczak RF, Bhakta V, Derda R, Sheffield WP.   +5 more
europepmc   +1 more source

Purification and Characterization of an Neutral Proteinase Inhibitor from Bovine Neutrophils [PDF]

, 1987
Hintz, Petra, Jochum, Marianne, Mossmann, Horst   +2 more
core   +1 more source

Lima bean proteinase inhibitor. Origins of circular dichroism bands and modification by Br2- and (CNS)2-.

, 1979
Ernest Kay, Barry M. Gumbiner
openalex   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

International Journal of COPD, 2008
Caroline A OwenDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAAbstract: Since the early 1960s, a compelling body of evidence has accumulated to show that proteinases ...
Caroline A Owen
doaj  

Structure-function relationships of proteinase inhibitors from soybean (Bowman-Birk) and lima bean. Modification by N-acetylimidazole.

, 1979
Ernest Kay
openalex   +1 more source