Advanced Functional Materials, EarlyView.Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen +5 more
wiley +1 more source
The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice. [PDF]
Biomed Res Int, 2018 Bortolozzo ASS +16 more
europepmc +1 more source
In vitro synthesis of pre-proteins of vacuolar compartmented proteinase inhibitors that accumulate in leaves of wounded tomato plants [PDF]
, 1980 Christopher E. Nelson, Clarence A. Ryan
openalex +1 more source
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
Advanced Functional Materials, EarlyView.Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh +3 more
wiley +1 more source
Proteinase Binding and Inhibition by the Monomeric α-Macroglobulin Rat α1-Inhibitor-3
, 1989 Jan J. Enghild +3 more
openalex +1 more source
Interleukin inhibition by a parasite proteinase inhibitor, taeniaestatin. [PDF]
, 1986 R. Wes Leid +3 more
openalex +1 more source
Advanced Functional Materials, EarlyView.CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao +11 more
wiley +1 more source
Measurement of the α1-proteinase inhibitor (α1-antitrypsin) of common marmoset and intestinal protein loss in wasting syndrome. [PDF]
Biosci Rep, 2019 Niimi K +6 more
europepmc +1 more source
Molecular basis for defective secretion of the Z variant of human alpha-1-proteinase inhibitor: secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342. [PDF]
, 1989 Ardythe A. McCracken +2 more
openalex +1 more source
Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury
Advanced Functional Materials, EarlyView.After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen +9 more
wiley +1 more source