Results 321 to 330 of about 194,365 (341)
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HUMAN PLASMA PROTEINASE INHIBITORS
Annual Review of Biochemistry, 1983PERSPECTIVES AND SUMMARy 655 INTRODUCTION 657 MECHANISM OF ACTION OF PROTEINASE INHIBITORS 659 The Standard Mechanism 660 Deviations Jrom the Standard M echanism 661 ALPHA I-PROTEINASE INHIBITOR 663 Polymorphysm oj (x, Proteinase Inhibitor 665 Mechanism Studies 667 Physiological Role of (x, Proteinase Inhibitor 672 ANTITHROMBIN III ...
Guy S. Salvesen, James Travis
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Proteinase 3 phosphonic inhibitors
Biochimie, 2019Neutrophils are one of the most important military services of the armed forces of the immune system, a crucial line of defense against bacterial or fungal onslaughts. One of their mechanisms of action relies on the production of serine proteases.
Renata Grzywa +3 more
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Expert Opinion on Investigational Drugs, 1994
This article briefly describes the identification of HIV proteinase as a potential target for antiviral chemotherapy, and discusses some of the strategies which have been used to discover inhibitors of this essential viral enzyme. Preclinical efficacy data are presented for selected inhibitors, and the ability of such compounds to generate a virus with
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This article briefly describes the identification of HIV proteinase as a potential target for antiviral chemotherapy, and discusses some of the strategies which have been used to discover inhibitors of this essential viral enzyme. Preclinical efficacy data are presented for selected inhibitors, and the ability of such compounds to generate a virus with
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Update on a proteinase inhibitor
Aids, 1994HIV PROTEINASE INHIBITORS: The HIV proteinase enzyme has been identified as a potential target for antiretroviral therapy, as inhibition of this enzyme leads to the generation of immature, non-infectious virions. There are several proteinase inhibitors in development; the first to enter clinical trials was saquinavir.
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Chapter 11 Proteinase families and their inhibitors
2001Publisher Summary This chapter reviews the classification and biochemical properties of proteinases and their inhibitors. The chapter emphasizes on the three proteolytic systems that mediate apoptosis in various cell types: caspases, calpains, and proteasome. It intends to be a practical guide on the proper use of proteinase inhibitors.
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Proteinases and their inhibitors in the immune system
2003The most important roles of proteinases in the immune system are found in apoptosis and major histocompatibility complex (MHC) class II-mediated antigen presentation. A variety of cysteine proteinases, serine proteinases, and aspartic proteinases as well as their inhibitors are involved in the regulation of apoptosis in neutrophils, monocytes, and ...
Marco van Eijk +3 more
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Biochemistry of Natural Proteinase Inhibitors
Angewandte Chemie International Edition in English, 1974AbstractThe natural inhibitors of proteolytic enzymes are proteins. These inhibitors associate reversibly with the enzymes to form stoichiometric protein‐protein complexes, in which substrate‐analogous association at the active center of the enzyme results in competitive inhibition of all catalytic functions.
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1980
Reports of myelin basic protein (MBP) fragments [2,11] and raised proteolytic activity [8] in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients in exacerbation are indicative of inflammatory demyelination. Basic protein is highly susceptible to digestion by the neutral proteinases of polymorphonuclear leucocytes (PMNL) and macrophages ...
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Reports of myelin basic protein (MBP) fragments [2,11] and raised proteolytic activity [8] in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients in exacerbation are indicative of inflammatory demyelination. Basic protein is highly susceptible to digestion by the neutral proteinases of polymorphonuclear leucocytes (PMNL) and macrophages ...
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1976
The capacity of plasma and serum to inhibit proteinases was recognized nearly a century ago and this phenomenon has been studied extensively since. It is not the purpose of this chapter to discuss the early work in any detail; this has been done elsewhere.1 In the last decade, the chemical identity of several plasma proteinase inhibitors has been ...
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The capacity of plasma and serum to inhibit proteinases was recognized nearly a century ago and this phenomenon has been studied extensively since. It is not the purpose of this chapter to discuss the early work in any detail; this has been done elsewhere.1 In the last decade, the chemical identity of several plasma proteinase inhibitors has been ...
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