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Pathogenesis and Current Treatment Strategies in Rheumatoid Arthritis: A Systematic Review Article.

Ann Afr Med
Deka D.
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Lysosomal proteinases

Acta Histochemica, 1987
A characteristic of lysosomal cysteine proteinases is given by their kinetic constants with specific substrates, their sequence homology, and their reactivity with monospecific polyclonal antibodies.
H, Kirschke, B, Wiederanders
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Proteinases and Proteinase Inhibitors

1992
The peritoneal cavity is well endowed with proteinases both in the parietal and viseral peritoneum as well as in the peritoneal fluid. Proteinases have a major role in activating and modulating the complement, coagulation, kinin, fibrinolytic, and extracellular matrix remodeling systems, and thus are critical components of the peritoneal response to ...
Gere S. diZerega, Kathleen E. Rodgers
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HIV proteinase inhibitors

Biochemical Society Transactions, 1992
513 IIIV proteinase is a member of the aspartic I Iurnan immunodeficiency virus (1 IlV), the causative agent of acquired immunodeficiency syndrome (AII)S)9 is a retrovirus. In common with other retroviruses and many other KNA viruses, some of its gene products are expressed in host cells as polyproteins which require subsequent processing by ...
N A, Roberts, J C, Craig, I B, Duncan
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Proteinase-Activated Receptors

Pharmacological Reviews, 2001
Proteinase-activated receptors are a recently described, novel family of seven-transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand receptor occupancy, activation is initiated by cleavage of the N terminus of the receptor by a serine protease resulting in the generation of a new tethered ligand that interacts with the ...
S R, Macfarlane, M J, Seatter, T, Kanke, G D, Hunter, R, Plevin   +4 more
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Acrosomal Proteinase and Proteinase Inhibitor of Human Spermatozoa

Science, 1972
The acrosomal proteinase of human spermatozoa was characterized and differs from other human proteinases. The enzyme has optimal activity at p H 8.0, is inactive below p H 5.0 or above p H 10.5, requires calcium for maximum activity, hydrolyzes fibrinogen, gelatin, and
L J, Zaneveld, B M, Dragoje, G F, Schumacher   +2 more
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Proteinase-Protein Inhibitor Interaction

Fibrinolysis, 1991
Until recently, the "substrate-like" "canonical" inhibition by the "small" serine proteinase inhibitors, and the product-like inhibition by the carboxypeptidase inhibitor, provided the only models for protein inhibitor-proteinase interactions. The recently published structures of cystatin/stefin-papain complexes and of hirudin-thrombin complexes reveal
W, Bode, R, Huber
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Collagenolytic proteinases in keratoconus

American Journal of Ophthalmology, 2006
To study the proteolytic phenomena contributing to the pathogenesis of keratoconus, corneal enzymes with potential to cleave fibrillar collagen were studied.Immunohistochemical labeling was undertaken of conventional and novel mammalian collagenases (MMP-1, -2, -8, -13, and -14) of the matrix metalloproteinase (MMP) family and other collagenolytic ...
Zygmunt, Mackiewicz, Marko, Määttä, Mathias, Stenman, Lasse, Konttinen, Timo, Tervo, Yrjö T, Konttinen   +5 more
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Proteinase‐activated receptor activation by coagulation proteinases

Drug Development Research, 2003
AbstractCoagulation proteinases signal through proteinase activated receptors (PARs). Thrombin‐dependent PAR signaling on platelets is essential for hemostasis, but regulation of inflammation by PAR‐signaling is increasingly recognized as an important aspect of other pro‐ and anticoagulant pathways.
Matthias Riewald, Wolfram Ruf
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