Results 271 to 280 of about 10,718,710 (345)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Genome-wide identification, characterization, and expression analyses of the solute carrier 2 (SLC2) gene family in fall armyworm (Spodoptera frugiperda). [PDF]

BMC Genomics
Zoghly HM, Ghallab AMK, Emam MM, Abdelbaky MA, Rashed MA, El-Sayed W, Abdelmaksoud EM.   +6 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Comprehensive profiling of Aβ40 and Aβ42 fibril-interacting proteins reveals PRKCG as a drug-targetable regulator of amyloidogenesis in Alzheimer's disease. [PDF]

Alzheimers Dement
Montero-Calle A, Coronel R, Manosalva J, Megías D, de Los Ríos V, Rábano A, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Liste I, Barderas R.   +10 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Protein structure-informed bacteriophage genome annotation with Phold. [PDF]

Nucleic Acids Res
Bouras G, Grigson SR, Mirdita M, Heinzinger M, Papudeshi B, Mallawaarachchi V, Green R, Kim RS, Mihalia V, Psaltis AJ, Wormald PJ, Vreugde S, Steinegger M, Edwards RA.   +13 more
europepmc   +1 more source

Layer-Specific Proteomic Profiling of the Human Cornea Reveals Insights Into Structure and Biological Function. [PDF]

Invest Ophthalmol Vis Sci
Schadwinkel HM, Nissen P, Moritz M, Linke SJ, Hassenstein A, Lohner L, Hellwinkel O, Schlüter H, Spitzer MS, Steuernagel M, Hahn J.   +10 more
europepmc   +1 more source

Salivary proteomics of patients with type 2 diabetes identify potential biomarkers for diabetes and highlight significant role of immune response. [PDF]

Clin Exp Med
Zhang Y, Huang Y, Zheng Y, Liang Y, Yue M, Zhu H, Wang Y, Huang Y.   +7 more
europepmc   +1 more source

Membranous Interacting Partners of Phage-Type Plastid RNA Polymerase Have Limited Impact on Plastid Gene Expression During Chloroplast Development. [PDF]

Plant Direct
Kurotaki Y, Hagiwara Y, Noto K, Nishino AS, Fujii S.   +4 more
europepmc   +1 more source

Probing the proteome. [PDF]

Elife
Lin WH, Cheng CL.
europepmc   +1 more source