Results 291 to 300 of about 10,300,849 (340)

All-atom empirical potential for molecular modeling and dynamics studies of proteins.

Journal of Physical Chemistry B, 1998
New protein parameters are reported for the all-atom empirical energy function in the CHARMM program. The parameter evaluation was based on a self-consistent approach designed to achieve a balance between the internal (bonding) and interaction ...
Alexander D. MacKerell, D. Bashford, M. Bellott, R. Dunbrack, J. Evanseck, M. Field, S. Fischer, J. Gao, H. Guo, S. Ha, D. Joseph-McCarthy, L. Kuchnir, K. Kuczera, F. Lau, C. Mattos, S. Michnick, T. Ngo, D. Nguyen, B. Prodhom, W. Reiher, B. Roux, M. Schlenkrich, J. Smith, R. Stote, J. Straub, M. Watanabe, J. Wiórkiewicz-Kuczera, D. Yin, M. Karplus   +28 more
semanticscholar   +1 more source

DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS *

Annals of the New York Academy of Sciences, 1964
The technique of disc electrophoresis has been presented, including a discussion of the technical variables with special reference to the separation of protein fractions of normal human serum.
B. Davis
semanticscholar   +1 more source

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

, 1949
The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story. For instance, there are the compounds of iron, which is carried in our blood plasma by a globulin, two atoms of iron to ...
G. Scatchard
semanticscholar   +1 more source

Imaging Intracellular Fluorescent Proteins at Nanometer Resolution

Science, 2006
We introduce a method for optically imaging intracellular proteins at nanometer spatial resolution. Numerous sparse subsets of photoactivatable fluorescent protein molecules were activated, localized (to ∼2 to 25 nanometers), and then bleached.
E. Betzig, G. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. Bonifacino, M. Davidson, J. Lippincott-Schwartz, H. Hess   +8 more
semanticscholar   +1 more source

Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.

Journal of Molecular Biology, 2000
A neural network-based tool, TargetP, for large-scale subcellular location prediction of newly identified proteins has been developed. Using N-terminal sequence information only, it discriminates between proteins destined for the mitochondrion, the ...
O. Emanuelsson, Henrik Nielsen, S. Brunak, G. Heijne   +3 more
semanticscholar   +1 more source

Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.

Analytical Chemistry, 1996
Proteins from silver-stained gels can be digested enzymatically and the resulting peptide analyzed and sequenced by mass spectrometry. Standard proteins yield the same peptide maps when extracted from Coomassie- and silver-stained gels, as judged by ...
A. Shevchenko, M. Wilm, O. Vorm, Millard F. Mann   +3 more
semanticscholar   +1 more source

A second generation force field for the simulation of proteins

, 1995
We present the derivation of a new molecular mechanical force field for simulating the structures, conformational energies, and interaction energies of proteins, nucleic acids, and many related organic molecules in condensed phases.
W. Cornell, P. Cieplak, C. Bayly, I. Gould, K. Merz, D. Ferguson, D. Spellmeyer, T. Fox, J. Caldwell, P. Kollman   +9 more
semanticscholar   +1 more source

Alzheimer's disease: genes, proteins, and therapy.

Physiological Reviews, 2001
Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and association cortices.
D. Selkoe
semanticscholar   +1 more source

NMR of proteins and nucleic acids

, 1988
Introduction and Survey. THE FOUNDATIONS: STRUCTURE AND NMR OF BIOPOLYMERS. NMR of Amino Acid Residues and Mononucleotides. NMR Spectra of Proteins and Nucleic Acids in Solution. The NMR Assignment Problem in Biopolymers.
K. Wüthrich
semanticscholar   +1 more source

A statistical model for identifying proteins by tandem mass spectrometry.

Analytical Chemistry, 2003
A statistical model is presented for computing probabilities that proteins are present in a sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a proteolytic digest of the sample.
A. Nesvizhskii, Andrew Keller, E. Kolker, R. Aebersold   +3 more
semanticscholar   +1 more source