Results 301 to 310 of about 10,300,849 (340)

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

Science, 1994
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the ...
J. Darnell, I. Kerr, George Stark Stark
semanticscholar   +1 more source

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

Annual Review of Immunology, 1998
The transcription factor NF-kappa B, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-kappa B in the expression of numerous cytokines and adhesion molecules has supported its role as an ...
S. Ghosh, M. May, E. Kopp
semanticscholar   +1 more source

Acute-phase proteins and other systemic responses to inflammation.

New England Journal of Medicine, 1999
A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation. In 1930 interest was focused on these changes by the discovery of C-reactive protein (so named because it reacted with
C. Gabay, I. Kushner
semanticscholar   +1 more source

G proteins: transducers of receptor-generated signals.

Annual Review of Biochemistry, 1987
PERSPECTIVES AND SUMMARy ......... .. ........ . ...... 615 HISTORy ....... ...... . . . . . ...... . . .. .... . . . .. . 616 INDIVIDUAL G PROTEINS: FUNCTIONS AND MOLECULAR ENTITIES 617 Criter ia for In volvemen t o f a G Pr otein ..... .........
A. Gilman
semanticscholar   +1 more source

Intrinsically unstructured proteins and their functions

Nature Reviews Molecular Cell Biology, 2005
H Jane Dyson, Peter E Wright, Patrick S Sullivan   +2 more
exaly   +2 more sources

Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.

Annual Review of Physiology, 1999
Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous feature of cells in which these proteins cope with stress-induced denaturation of other proteins.
M. Feder, G. Hofmann
semanticscholar   +1 more source

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

, 1996
▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes,
A. Baldwin
semanticscholar   +1 more source

Mechanics of Motor Proteins and the Cytoskeleton

, 2001
Preface - Introduction - PART I: PHYSICAL PRINCIPLES - Mechanical Forces - Mass, Stiffness, and Damping of Proteins - Thermal Forces and Diffusion - Chemical Forces - Polymer Mechanics - PART II: CYTOSKELETON - Structures of Cytoskeletal Filaments ...
J. Howard, R. Clark
semanticscholar   +1 more source

The role of Atg proteins in autophagosome formation.

Annual Review of Cell and Developmental Biology, 2011
Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane ...
N. Mizushima, T. Yoshimori, Y. Ohsumi
semanticscholar   +1 more source

Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels

, 1987
A new modification of silver staining is presented which utilizes two chemical properties of thiosulfate: image enhancement by pretreatment of fixed gels, and formation of soluble silver complexes which prevents unspecific background staining during ...
H. Blum, H. Beier, H. Gross
semanticscholar   +1 more source