Results 331 to 340 of about 13,339,631 (403)

All-atom empirical potential for molecular modeling and dynamics studies of proteins.

Journal of Physical Chemistry B, 1998
New protein parameters are reported for the all-atom empirical energy function in the CHARMM program. The parameter evaluation was based on a self-consistent approach designed to achieve a balance between the internal (bonding) and interaction ...
Alexander D. MacKerell, D. Bashford, M. Bellott, R. Dunbrack, J. Evanseck, M. Field, S. Fischer, J. Gao, H. Guo, S. Ha, D. Joseph-McCarthy, L. Kuchnir, K. Kuczera, F. Lau, C. Mattos, S. Michnick, T. Ngo, D. Nguyen, B. Prodhom, W. Reiher, B. Roux, M. Schlenkrich, J. Smith, R. Stote, J. Straub, M. Watanabe, J. Wiórkiewicz-Kuczera, D. Yin, M. Karplus   +28 more
semanticscholar   +1 more source

Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.

Journal of Molecular Biology, 2000
A neural network-based tool, TargetP, for large-scale subcellular location prediction of newly identified proteins has been developed. Using N-terminal sequence information only, it discriminates between proteins destined for the mitochondrion, the ...
O. Emanuelsson, Henrik Nielsen, S. Brunak, G. Heijne   +3 more
semanticscholar   +1 more source

Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.

Analytical Chemistry, 1996
Proteins from silver-stained gels can be digested enzymatically and the resulting peptide analyzed and sequenced by mass spectrometry. Standard proteins yield the same peptide maps when extracted from Coomassie- and silver-stained gels, as judged by ...
A. Shevchenko, M. Wilm, O. Vorm, Millard F. Mann   +3 more
semanticscholar   +1 more source

A second generation force field for the simulation of proteins

, 1995
We present the derivation of a new molecular mechanical force field for simulating the structures, conformational energies, and interaction energies of proteins, nucleic acids, and many related organic molecules in condensed phases.
W. Cornell, P. Cieplak, C. Bayly, I. Gould, K. Merz, D. Ferguson, D. Spellmeyer, T. Fox, J. Caldwell, P. Kollman   +9 more
semanticscholar   +1 more source

Alzheimer's disease: genes, proteins, and therapy.

Physiological Reviews, 2001
Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has arisen from the application of molecular and cell biology to this complex disorder of the limbic and association cortices.
D. Selkoe
semanticscholar   +1 more source

Analysis of Protein-Protein Interactions by Protein Microarrays

2021
The analysis of the proteome and the interactome would be useful for a better understanding of the pathophysiology of several disorders, allowing the identification of potential specific markers for early diagnosis and prognosis, as well as potential targets of intervention.
Rodrigo Barderas, Ana Montero-Calle
openaire   +3 more sources

A statistical model for identifying proteins by tandem mass spectrometry.

Analytical Chemistry, 2003
A statistical model is presented for computing probabilities that proteins are present in a sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a proteolytic digest of the sample.
A. Nesvizhskii, Andrew Keller, E. Kolker, R. Aebersold   +3 more
semanticscholar   +1 more source

NMR of proteins and nucleic acids

, 1988
Introduction and Survey. THE FOUNDATIONS: STRUCTURE AND NMR OF BIOPOLYMERS. NMR of Amino Acid Residues and Mononucleotides. NMR Spectra of Proteins and Nucleic Acids in Solution. The NMR Assignment Problem in Biopolymers.
K. Wüthrich
semanticscholar   +1 more source

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

Science, 1994
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the ...
J. Darnell, I. Kerr, George Stark Stark
semanticscholar   +1 more source

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

Annual Review of Immunology, 1998
The transcription factor NF-kappa B, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-kappa B in the expression of numerous cytokines and adhesion molecules has supported its role as an ...
S. Ghosh, M. May, E. Kopp
semanticscholar   +1 more source