Results 241 to 250 of about 126,260 (296)

Surgical Outcomes Following Neoadjuvant‐Targeted Therapy for Advanced Differentiated Thyroid Cancer—Real‐World Data

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Background Differentiated thyroid carcinoma (DTC) is typically managed surgically with favourable outcomes. However, surgery may have dire consequences when the tumour invades critical structures. Neoadjuvant therapy with tyrosine kinase inhibitors (TKIs) has emerged as a potential strategy to improve resectability and reduce morbidity in ...
Alexandra Dorman   +15 more
wiley   +1 more source

Diabetes management in maternally inherited diabetes and deafness (MIDD): A review and a proposed treatment algorithm

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder usually caused by the variant m.3243A>G in the MT‐TL1 gene. We have proposed that diabetes in MIDD arises from a combination of insulin resistance and impaired β‐cell function that is more likely to occur in the presence of high skeletal muscle heteroplasmy and ...
Ahsen Chaudhry   +2 more
wiley   +1 more source

Estimating the risk of cardiovascular outcomes and all‐cause mortality in individuals with type 2 diabetes: Validation of the UKPDS outcomes model using TECOS and EXSCEL data

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate United Kingdom Prospective Diabetes Study Outcomes Model version 2 (UKPDS‐OM2) cardiovascular risk estimates for people with type 2 diabetes using TECOS and EXSCEL data. Materials and methods We compared model‐simulated and TECOS and EXSCEL observed event rates for the composite outcome of cardiovascular death, myocardial ...
Ruth L. Coleman   +4 more
wiley   +1 more source

Continuous glucose monitoring and microvascular complications in diabetes: Bridging glycemic metrics with clinical outcomes

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Continuous glucose monitoring (CGM) has emerged as a complementary and more dynamic method for evaluating glycemic control in people with diabetes. Relevant studies examining the association between CGM parameters, including time in range (TIR), glycemic variability (GV), and time in tight range (TITR), and diabetic nephropathy, retinopathy ...
Lilian Anagnostopoulou   +4 more
wiley   +1 more source

Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular–kidney–metabolic conditions: A pooled analysis of randomised trials

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Background Albuminuria is associated with an increased risk of cardiovascular and kidney events. Sodium glucose co‐transporter 2 inhibitors (SGLT2i) reduce albuminuria and improve kidney outcomes in patients with albuminuric chronic kidney disease (CKD).
João Pedro Ferreira   +10 more
wiley   +1 more source

Efficacy and safety of glucagon‐like peptide 1 receptor agonists across all health outcomes in type 2 diabetes: An umbrella review and evidence map of randomised controlled trials

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aim Glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) have been established as effective treatments for type 2 diabetes, offering benefits beyond glycaemic control; however, their associations across multiple health outcomes remain insufficiently assessed.
Dongjin Yeo   +8 more
wiley   +1 more source

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