Results 91 to 100 of about 10,190 (249)

Proteogenomics: New Emerging Technology

HAYATI Journal of Biosciences, 2016
The term proteogenomics is basically the integration of proteomics with genomics and transcriptomics. Today, proteogenomics is developing on the way to combined understanding about overall cellular functions. At present globally, structure of genes, expression of genes (in the form of mRNA synthesis), synthesis of proteins (translation of mRNA) and ...
Wasim Sajjad, Muhammad Rafiq, Barkat Ali, Muhammad Hayat, Sahib Zada, Wasim Sajjad, Tanweer Kumar   +6 more
openaire   +2 more sources

The proteogenomic path towards biomarker discovery [PDF]

Pediatric Transplantation, 2008
Abstract:  The desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. However, the task is daunting and requires collaborations among researchers working in the fields of ...
Tara K, Sigdel, Minnie M, Sarwal
openaire   +2 more sources

Proteogenomic and metabolomic characterization of human glioblastoma [PDF]

, 2021
Liang-Bo Wang, Alla Karpova, Marina Gritsenko, Jennifer Kyle, Song Cao, Yize Li, Dmitry Rykunov, Antonio Colaprico, Joseph H. Rothstein, Runyu Hong, Vasileios Stathias, MacIntosh Cornwell, Francesca Petralia, Yige Wu, Boris Reva, Karsten Krug, Pietro Pugliese, Emily Kawaler, Lindsey K. Olsen, Wen-Wei Liang, Xiaoyu Song, Yongchao Dou, Michael C. Wendl, Wagma Caravan, Wenke Liu, Daniel Cui Zhou, Jiayi Ji, Chia‐Feng Tsai, Vladislav Petyuk, Jamie Moon, Weiping Ma, Rosalie Chu, Karl Weitz, Ronald Moore, Matthew Monroe, Rui Zhao, Xiaolu Yang, Seungyeul Yoo, Azra Krek, Alexis Demopoulos, Houxiang Zhu, Matthew A. Wyczalkowski, Joshua F. McMichael, Brittany Henderson, Caleb M. Lindgren, Hannah Boekweg, Shuangjia Lu, Jessika Baral, Lijun Yao, Kelly G. Stratton, Lisa Bramer, Erika Zink, Sneha Couvillion, Kent Bloodsworth, Shankha Satpathy, Weiva Sieh, Simina M. Boca, Stephan C. Schürer, Feng Chen, Maciej Wiznerowicz, Karen A. Ketchum, Emily S. Boja, Christopher R. Kinsinger, Ana I. Robles, Tara Hiltke, Mathangi Thiagarajan, Alexey I. Nesvizhskii, Bing Zhang, D.R. Mani, Michele Ceccarelli, Xi S. Chen, Sandra Cottingham, Qing Kay Li, Albert H. Kim, David Fenyö, Kelly V. Ruggles, Henry Rodriguez, Mehdi Mesri, Samuel Payne, Adam Resnick, Pei Wang, Richard Smith, Antonio Iavarone, Milan G. Chheda, Jill S. Barnholtz‐Sloan, Karin Rodland, Tao Liu, Li Ding, Anupriya Agarwal, Mitual Amin, Eunkyung An, Matthew L. Anderson, David W. Andrews, Thomas Bauer, Chet Birger, Michael J. Birrer, Lili M. Blumenberg, William Bocik, Uma Borate, Melissa Borucki   +99 more
openalex   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Cell, 2022
M. Guilliams, J. Bonnardel, Birthe Haest, B. Vanderborght, Camille Wagner, Anneleen Remmerie, A. Bujko, L. Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, C. Zwicker, F. Svedberg, Tineke Vanhalewyn, Amanda Gonçalves, S. Lippens, B. Devriendt, E. Cox, Giuliano Ferrero, V. Wittamer, A. Willaert, S. Kaptein, J. Neyts, K. Dallmeier, P. Geldhof, Stijn Casaert, B. Deplancke, P. ten Dijke, A. Hoorens, A. Vanlander, F. Berrevoet, Y. Van Nieuwenhove, Y. Saeys, Wouter Saelens, H. Van Vlierberghe, L. Devisscher, Charlotte L. Scott   +37 more
semanticscholar   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma

International Journal of Cancer, Volume 158, Issue 4, Page 858-865, 15 February 2026.
What's new? Lung adenocarcinoma shows considerable heterogeneity in disease progression and therapeutic response. Here, the authors analyzed tumor samples through proteomic profiling and applied network‐based clustering. They identified two distinct patient groups with different demographic, clinical, and molecular characteristics.
Ujjwal Neogi, Anoop T. Ambikan, Kati Turkowski, Marc A. Schneider, Vanessa M. Beutgen, Johannes Graumann, Hauke Winter, Marek Bartkuhn, Werner Seeger, Soni S. Pullamsetti, Rajkumar Savai   +10 more
wiley   +1 more source

The Proteogenomics of Prostate Cancer Radioresistance [PDF]

Cancer Research Communications
Abstract Prostate cancer is frequently treated with radiotherapy. Unfortunately, aggressive radioresistant relapses can arise, and the molecular underpinnings of radioresistance are unknown.
Roni Haas, Gavin Frame, Shahbaz Khan, Beth K. Neilsen, Boon Hao Hong, Celestia P.X. Yeo, Takafumi N. Yamaguchi, Enya H.W. Ong, Wenyan Zhao, Benjamin Carlin, Eugenia L.L. Yeo, Kah Min Tan, Yuan Zhe Bugh, Chenghao Zhu, Rupert Hugh-White, Julie Livingstone, Dennis J.J. Poon, Pek Lim Chu, Yash Patel, Shu Tao, Vladimir Ignatchenko, Natalie J. Kurganovs, Geoff S. Higgins, Michelle R. Downes, Andrew Loblaw, Danny Vesprini, Amar U. Kishan, Melvin L.K. Chua, Thomas Kislinger, Paul C. Boutros, Stanley K. Liu   +30 more
openaire   +3 more sources

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

Credentialing Individual Samples for Proteogenomic Analysis

Molecular & Cellular Proteomics, 2018
An integrated analysis of DNA, RNA and protein, so called proteogenomic studies, has the potential to greatly increase our understanding of both normal physiology and disease development. However, such studies are challenged by a lack of a systematic approach to credential individual samples resulting in the introduction of noise into the system that ...
Wei, Zhao, Jun, Li, Rehan, Akbani, Han, Liang, Gordon B, Mills   +4 more
openaire   +2 more sources