Results 61 to 70 of about 10,190 (249)

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms

Nature Cancer, 2021
Despite major advancements in lung cancer treatment, long-term survival is still rare and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune-evasion mechanisms.
J. Lehtiö, T. Arslan, I. Siavelis, Yanbo Pan, F. Socciarelli, O. Berkovska, Husen M. Umer, G. Mermelekas, Mohammad Pirmoradian, M. Jönsson, H. Brunnström, O. Brustugun, K. Purohit, Richard Cunningham, Hassan Foroughi Asl, S. Isaksson, E. Arbajian, Mattias Aine, Anna Karlsson, Marija Kotevska, Carsten Gram Hansen, Vilde Drageset Haakensen, Å. Helland, D. Tamborero, H. Johansson, R. Branca, M. Planck, J. Staaf, L. Orre   +28 more
semanticscholar   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics [PDF]

, 2016
Introduction: The last 20 years have seen significant improvements in the analytical capabilities of biological mass spectrometry. Studies using advanced mass spectrometry (MS) have resulted in new insights into cell biology and the aetiology of diseases
Cramer, Rainer, Hale, Oliver J., Timms, John F.   +2 more
core   +1 more source

An analysis of proteogenomics and how and when transcriptome-informed reduction of protein databases can enhance eukaryotic proteomics

Genome Biology, 2022
Proteogenomics aims to identify variant or unknown proteins in bottom-up proteomics, by searching transcriptome- or genome-derived custom protein databases.
L. Fancello, Thomas Burger
semanticscholar   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Improvement of peptide identification with considering the abundance of mRNA and peptide [PDF]

, 2017
Scripts used for data analysis in this study.
Bo Wen, Chunwei Ma, Geng Liu, Shaohang Xu, Siqi Liu, Xin Liu, Xun Xu   +6 more
core   +4 more sources

Improving the genome and proteome annotations of the marine model diatom Thalassiosira pseudonana using a proteogenomics strategy

Marine Life Science & Technology, 2023
Diatoms are unicellular eukaryotic phytoplankton that account for approximately 20% of global carbon fixation and 40% of marine primary productivity; thus, they are essential for global carbon biogeochemical cycling and climate.
Xiao-Huang Chen, Mingkun Yang, Yuan-Yuan Li, Zhang-Xian Xie, Shu-Feng Zhang, M. Töpel, Shady A. Amin, Lin Lin, F. Ge, Dazhi Wang   +9 more
semanticscholar   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Long Noncoding RNAs are Rarely Translated in Two Human Cell Lines [PDF]

, 2012
Data from the Encyclopedia of DNA Elements (ENCODE) project show over 9640 human genome loci classified as long noncoding RNAs (lncRNAs), yet only ~100 have been deeply characterized to determine their role in the cell.
Giddings, Morgan, Khatun, Jainab, Risk, Brian   +2 more
core   +2 more sources

The age of data-driven proteomics : how machine learning enables novel workflows [PDF]

, 2020
A lot of energy in the field of proteomics is dedicated to the application of challenging experimental workflows, which include metaproteomics, proteogenomics, data independent acquisition (DIA), non-specific proteolysis, immunopeptidomics, and open ...
Bergstra J., Bojarski M., Boser B. E., Deutsch E. W., Ho T. K., Montufar G. F., Searle B. C., Serrano G., Silva A. S. C., Simonyan K., Young S. R., Zimmer D.   +11 more
core   +2 more sources