Results 201 to 210 of about 13,195 (282)

Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells. [PDF]

Angew Chem Int Ed Engl
Ashry R, Abdelsalam M, Hausen J, Hieber C, Zeyn Y, Sarnow AC, Schmidt M, Najafi S, Oehme I, Bros M, Chen JX, Dejung M, Sippl W, Krämer OH.   +13 more
europepmc   +1 more source

Proteolysis targeting chimera technology: a novel strategy for treating diseases of the central nervous system. [PDF]

Neural Regen Res, 2021
Ma K, Han XX, Yang XM, Zhou SL.
europepmc   +1 more source

Correction to 'Proteolysis Targeting Chimera Loaded Extracellular Vesicles for Developing Triple Negative Breast Cancer Treatment'. [PDF]

J Extracell Vesicles
europepmc   +1 more source

PROteolysis TArgeting Chimera (PROTAC) Estrogen Receptor Degraders for Treatment of Estrogen Receptor-Positive Advanced Breast Cancer. [PDF]

Target Oncol
Hamilton EP, Jeselsohn RM, Vahdat LT, Hurvitz SA.   +3 more
europepmc   +1 more source

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders. [PDF]

ChemMedChem
Almodóvar-Rivera CM, Tandon I, Mudududdla R, Esguerra PN, Lucio-Acero K, Tang W.   +5 more
europepmc   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, Volume 13, Issue 27, 13 May 2026.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Correction to "Proteolysis-targeting chimera (PROTAC): current applications and future directions". [PDF]

MedComm (2020)
europepmc   +1 more source

Ionomycin-activated calpain triggers apoptosis [PDF]

, 2002
Adams, Arthur, Bepler, Berridge, Berridge, Buki, Chai, Chen, Cheng, Chinnaiyan, Clem, Deveraux, Diaz, Eto, Farrow, Fujita, Furuya, Gabrijelcic-Geiger, Goping, Goyal, Grandgirard, Green, Gross, Hafner, Hengartner, Huang, Knepper-Nicolai, Kubbutat, Leist, Li, Liu, Matsumura, McGahon, Molinari, Murphy, Murphy, Nakagawa, O'Donovan, Pinton, Porn-Ares, Potter, Raff, Ray, Reed, Riedl, Roy, Ruiz-Vela, Saido, Salvesen, Sasaki, Smith, Squier, Srinivasula, Stennicke, Stoka, Strack, Suzuki, Thompson, Thornberry, Varghese, Wang, Waterhouse, Wolf, Xie, Yin, Youn, Zamzami   +66 more
core   +2 more sources

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source