Results 231 to 240 of about 13,195 (282)

L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells

Cancer Science, Volume 117, Issue 5, Page 1380-1396, May 2026.
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma, Daisuke Kanematsu, Yukako Handa, Tomoko Shofuda, Atsuyo Yamamoto, Kayo Nishitani, Zhize Xiao, Daisuke Kawauchi, Kentarou Baba, Naoyuki Inagaki, Yonehiro Kanemura   +10 more
wiley   +1 more source

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera. [PDF]

J Am Chem Soc
Bond AG, Muñoz I Ordoño M, Bisbach CM, Craigon C, Makukhin N, Caine EA, Nagala M, Urh M, Winter GE, Riching KM, Ciulli A.   +10 more
europepmc   +1 more source

Talquetamab: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Talquetamab is a first‐in‐class, T‐cell–redirecting bispecific antibody targeting GPRC5D, a novel antigen highly expressed on malignant plasma cells with limited expression in normal tissues. Despite advances in treatment, multiple myeloma (MM) remains incurable, and talquetamab offers a promising therapeutic option for patients with relapsed ...
Yibo Wang, Jue Gong, Nicholas Au, Jie Zhou, Dongfen Yuan, Jaszianne Tolbert, Guoqiang Zhang, Deeksha Vishwamitra, Jenny Zhang, Nahor Haddish‐Berhane, Indrajeet Singh   +10 more
wiley   +1 more source

Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy. [PDF]

EBioMedicine
Zhang D, Ma B, Liu D, Wu W, Zhou T, Gao Y, Yang C, Jian Y, Fan Y, Qian Y, Ma J, Gao Y, Chen Y, Xu S, Li L.   +14 more
europepmc   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

CTNNB1 Genetic Variation and Its Interaction With DLK1 in Type 2 Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This graphical abstract illustrates the integrated study of CTNNB1 and DLK1 interaction in type 2 diabetes mellitus (T2DM). Combining bioinformatics, human genetic analysis, and HFD‐induced mouse models, it shows CTNNB1 and DLK1 synchronous downregulation in T2DM, the protective effect of CTNNB1 rs1798802 GG genotype, and cooperative colocalization of ...
Xiaoxue Gan, Yilinuer Adeerjiang, Min Xu, Xuan He, Sheng Jiang, Guoli Du   +5 more
wiley   +1 more source

Proteolysis Targeting Chimera Agents (PROTACs): New Hope for Overcoming the Resistance Mechanisms in Oncogene-Addicted Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Cordani N, Nova D, Sala L, Abbate MI, Colonese F, Cortinovis DL, Canova S.   +6 more
europepmc   +1 more source

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions. [PDF]

Bioconjug Chem
Kamaraj R, Ghosh S, Das S, Sen S, Kumar P, Majumdar M, Dasgupta R, Mukherjee S, Das S, Ghose I, Pavek P, Raja Karuppiah MP, Chuturgoon AA, Anand K.   +13 more
europepmc   +1 more source

Exploring Orodispersible Films Containing the Proteolysis Targeting Chimera ARV-110 in Hot Melt Extrusion and Solvent Casting Using Polyvinyl Alcohol. [PDF]

Pharmaceutics
Meloni V, Halstenberg L, Mareczek L, Lu J, Liang B, Gottschalk N, Mueller LK.   +6 more
europepmc   +1 more source

Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. [PDF]

J Am Chem Soc
Wang Z, Zhang D, Qiu X, Inuzuka H, Xiong Y, Liu J, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W.   +12 more
europepmc   +1 more source