The model of proteolysis [PDF]
, 2010 This document presents the original approach for estimating parameters of proteolysis process. Data used to fit the model are taken from mass spectrometric experiments. For parameters estimation the Levenberg-Marquadt algorithm is used.
Anna Gambin, Piotr Dittwald
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Comparative Analysis of the Major Polypeptides from Liver Gap Junctions and Lens Fiber Junctions [PDF]
, 1982 Gap junctions from rat liver and fiber junctions from bovine lens have similar septilaminar profiles when examined by thin-section electron microscopy and differ only slightly with respect to the packing of intramembrane particles in freeze-fracture ...
Anderson, David J. +3 more
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Advanced Healthcare Materials, EarlyView.Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski +6 more
wiley +1 more source
Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions
Advanced Healthcare Materials, EarlyView.Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi +7 more
wiley +1 more source
Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells [PDF]
, 2013 Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells.
Apostolaki +47 more
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Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
Journal of Lipid Research, 1999 Newly synthesized apolipoprotein E (apoE) is incompletely secreted and partially degraded by hepatocytes. To evaluate current models concerning apoE's role in remnant lipoprotein clearance by the liver, we performed a detailed and quantitative pulse ...
Matthias Schmitt, Thierry Grand-Perret
doaj +1 more source
The Nicastrin ectodomain adopts a highly thermostable structure [PDF]
, 2011 Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight gamma-secretase complex. gamma-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the ...
Beyer, Klaus +6 more
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Role of Insulin-Like Growth Factor Binding Protein-2 and Its Limited Proteolysis in Neuroblastoma Cell Proliferation: Modulation by Transforming Growth Factor- and Retinoic Acid [PDF]
, 1997 M. Menouny
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Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress
, 2022 Chang Yeop Han +6 more
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