Results 281 to 290 of about 183,121 (297)

The course of proteolysis of lysozyme

Archives of Biochemistry and Biophysics, 1956
Abstract The course of proteolysis of lysozyme by chymotrypsin, trypsin, papain at three pH's, and pepsin is reported with tabulation of progressive exposure of 15 N-residue types and 12 C-residue types. A marked similarity in pattern of hydrolysis has been observed.
T L Hurst, Sidney W. Fox
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Proteolysis and Sterol Regulation

Annual Review of Cell and Developmental Biology, 2002
▪ Abstract  The mammalian cell continuously adjusts its sterol content by regulating levels of key sterol synthetic enzymes and levels of LDL receptors that mediate uptake of cholesterol-laden particles. Control is brought about by sterol-regulated transcription of relevant genes and by regulated degradation of the committed step enzyme HMG-CoA ...
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Hsp70s and lysosomal proteolysis

Experientia, 1994
Confluent cultured cells activate a lysosomal pathway of polypeptide breakdown in response to withdrawal of serum growth factors. The substrates for this proteolytic pathway are a restricted class of cytosolic polypeptides containing peptide sequences biochemically related to lysine-phenylalanine-glutamate-arginine-glutamine, or, in single amino acid ...
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Compartmentalization of Proteolysis

2013
Proteolysis is arguably the most important of all post-translational modifications in that it is effectively irreversible, and leads to the partial or complete breakdown of proteins. Cells have adapted various mechanisms to control proteolysis as despite its importance, its destructive nature requires tight regulation.
Margarete M. S. Heck, Christopher J. Scott, Klaudia Brix   +2 more
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Intramembrane proteolysis by presenilins

Nature Reviews Molecular Cell Biology, 2000
Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a ...
Harald Steiner, Christian Haass
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Proteolysis and Fertilization

1979
Participation of proteases in fertilization processes has been well documented recently. Proteases are involved, for example, in sperm migration and transport, induction of the acrosome reaction, penetration of spermatozoa through ovum layers, development of the fertilization membrane (polyspermy block), decondensation of chromatin after sperm-egg ...
A. Henschen, H. Fritz, W. Müller
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Measuring Proteolysis in Mitosis

2009
The targeted destruction of key regulators helps to drive the cell cycle. Here we describe a quantitative assay to measure destruction of different regulators in mitotic cells. This assay uses GFP-tagged substrates and time-lapse fluorescence microscopy of single cells to pinpoint the timing of destruction of different substrates at different stages in
Barbara Di Fiore, Catherine Lindon
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Peering into proteolysis with presenilins

Journal of Alzheimer's Disease, 2001
Presenilins were originally identified because they cause a neurodegenerative disease, but the impact of these proteins on the neuron appears to extend beyond neurodegeneration and into fundamental concepts of cell biology and development. Presenilins were identified as a result of the steady march of molecular genetics which first lead to ...
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Control of Proteolysis

Annual Review of Biochemistry, 1980
Holzer, Helmut, Heinrich, Peter
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Proteolysis and Toxoplasma invasion

International Journal for Parasitology, 2006
Apicomplexan parasites including Toxoplasma gondii cause widespread human and animal diseases, often with the most severe manifestations involving the central nervous system. The need for new therapeutic agents along with the fascinating biology of these parasites has fueled a keen interest in understanding how key steps in the life cycle are regulated.
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