Results 311 to 320 of about 390,280 (339)
Some of the next articles are maybe not open access.
2021
Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Niki Chondrogianni +2 more
openaire +2 more sources
Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Niki Chondrogianni +2 more
openaire +2 more sources
Current Opinion in Clinical Nutrition and Metabolic Care, 2001
The mechanisms of proteolysis remain to be fully defined. This review focuses on recent advances in our understanding of the ubiquitin-proteasome-dependent pathway, which is involved in the control of many major biological functions. The ubiquitinylation/deubiquitinylation system is a complex machinery responsible for the specific tagging and proof ...
Attaix, Didier +3 more
openaire +4 more sources
The mechanisms of proteolysis remain to be fully defined. This review focuses on recent advances in our understanding of the ubiquitin-proteasome-dependent pathway, which is involved in the control of many major biological functions. The ubiquitinylation/deubiquitinylation system is a complex machinery responsible for the specific tagging and proof ...
Attaix, Didier +3 more
openaire +4 more sources
1977
The presence of an enzyme associated with tropoelastin is described. The enzyme has a pH optimum between 7 and 9 and trypsin-like specificity. Upon incubation, tropoelastin (72,000 molecular weight) is cleaved into relatively high molecular weight fragments. In addition to the parent molecule, five discrete polypeptide bands are usually observed on SDS
R, Mecham, J A, Foster, C, Franzblau
openaire +2 more sources
The presence of an enzyme associated with tropoelastin is described. The enzyme has a pH optimum between 7 and 9 and trypsin-like specificity. Upon incubation, tropoelastin (72,000 molecular weight) is cleaved into relatively high molecular weight fragments. In addition to the parent molecule, five discrete polypeptide bands are usually observed on SDS
R, Mecham, J A, Foster, C, Franzblau
openaire +2 more sources
Studying Proteolysis Within Mitochondria
2007Mitochondria are dynamic organelles with activities that adjust to altering physiological conditions and variable metabolic demands. A conserved proteolytic system present within the organelle exerts essential functions during the biogenesis of mitochondria and ensures the maintenance of organellar activities under varying conditions.
Tatsuta, T., Langer, T.
openaire +3 more sources
Intramembrane proteolysis within lysosomes
Ageing Research Reviews, 2016Regulated intramembrane proteolysis is of pivotal importance in a diverse set of developmental and physiological processes. Altered intramembrane substrate turnover may be associated with neurodegeneration, cancer and impaired immune function. In this review we will focus on the intramembrane proteases which have been localized in the lysosomal ...
Bernd, Schröder, Paul, Saftig
openaire +2 more sources
Science's STKE, 2001
Some secreted growth factors originate as membrane-bound precursor proteins, and upon cleavage, they are released to act on their cognate receptors at the cell surface. Ligands for the epidermal growth factor (EGF) receptors are synthesized as such, but the mechanism and regulation of their cleavage have not been fully elucidated.
openaire +2 more sources
Some secreted growth factors originate as membrane-bound precursor proteins, and upon cleavage, they are released to act on their cognate receptors at the cell surface. Ligands for the epidermal growth factor (EGF) receptors are synthesized as such, but the mechanism and regulation of their cleavage have not been fully elucidated.
openaire +2 more sources
Ozone and Pulmonary Proteolysis
Annals of Internal Medicine, 1970Excerpt To the editor: In their editorial on antitrypsin deficiency Falk and Briscoe (Ann Intern Med72:427-429, 1970) point out that intrapulmonary proteolysis might be due to either decreased inhi...
openaire +2 more sources