Results 21 to 30 of about 264,068 (308)
SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity [PDF]
, 2018 Dysregulation of signaling pathways that control organ size, such as the AKT-mTOR and Hippo-YAP pathways, often leads to tumorigenesis and metastasis. The Hippo pathway effector YAP is a transcriptional co-activator overexpressed or activated in human ...
Fan Yao, Yutong Sun, Zhenna Xiao, Li Ma
core +1 more source
Mìžnarodnij Endokrinologìčnij Žurnal, 2019 Background. The relevance is due to rather understudied state of proteolytic reactions in case of diabetes mellitus (DM) with acute peritonitis (AP), which is increasingly common in the practice.
F.V. Grynchuk, A.F. Grynchuk
doaj +1 more source
Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito +6 more
core +1 more source
Proteolytic activity of Clostridium difficile [PDF]
Journal of Medical Microbiology, 1992 Ten isolates of Clostridium difficile expressing different degrees of toxigenicity and virulence in an animal model were assayed for the production of proteolytic enzymes by various methods. All strains demonstrated some activity in one or more of the assay systems. There was no direct correlation between toxigenic status and enzyme production. However,
S V, Seddon, S P, Borriello
openaire +2 more sources
Molecules, 2014 Proteolytic enzymes are important macromolecules in the regulation of biochemical processes in living organisms. Additionally, these versatile biomolecules have numerous applications in the industrial segment.
Yamara A. S. de Menezes +6 more
doaj +1 more source
, 2023 Proteolytic activity of the Gram-positive, proteolytic, psychrotrophic bacteria isolated from raw milk.
Siavash Maktabi (16979578) +4 more
core +1 more source
Lactoferrin impairs pathogen virulence through its proteolytic activity. [PDF]
Front Vet SciAntibiotics, often hailed as ‘miracle drugs’ in the 20th century, have revolutionised medicine by saving millions of lives in human and veterinary medicine, effectively combatting bacterial infections.
Ongena R +4 more
europepmc +2 more sources
Proteolytic Activation of Human Cathepsin A [PDF]
Journal of Biological Chemistry, 2014 Galactosialidosis is a human lysosomal storage disease caused by deficiency in the multifunctional lysosomal protease cathepsin A (also known as protective protein/cathepsin A, PPCA, catA, HPP, and CTSA; EC 3.4.16.5). Previous structural work on the inactive precursor human cathepsin A (zymogen) led to a two-stage model for activation, where ...
Nilima, Kolli, Scott C, Garman
openaire +2 more sources
Proteolytic activity in the heart of rats with hyperhomocysteinemia [PDF]
, 2022 Objective: The aim: To investigate the distribution of proteolytic activity and cytokine profile in the heart of rats with hyperhomocysteinemia. Patients and methods: Materials and methods: A total of 60 albino non-linear male rats was used in the study.
Maievskyi, O. +6 more
core +1 more source
Ascorbic Acid Content and Proteolytic Enzyme Activity of Microwave-Dried Pineapple Stem and Core
Chemical Engineering Transactions, 2017 Solid wastes generated from the industrial processing of pineapple are favourable raw materials for obtaining antioxidants and bioactive compounds because of their low cost and the possibility of reducing environmental problems caused by waste disposal ...
N.A.M. Zaki +3 more
doaj +1 more source