Results 201 to 210 of about 267,519 (299)

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Potential therapeutic targets for multisite chronic pain: A proteome-wide Mendelian randomization study. [PDF]

Medicine (Baltimore)
Gao J, Liu J.
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Decoding the Functional Proteome of <i>Vitis</i>: Past, Present, and Future. [PDF]

Plants (Basel)
Tomaz I, Jeromel A, Vončina D, Habuš Jerčić I, Lazarević B, Šikuten I, Hofer Geušić S, Preiner D.   +7 more
europepmc   +1 more source

Proteomics Projects: Interaction Proteome: New tools for proteomics [PDF]

Journal of Proteome Research, 2006
openaire   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Beyond Correlation: Constraint Architecture Explains Proteome-Metabolome Decoupling. [PDF]

Int J Mol Sci
Kim KH, Yoo BC.
europepmc   +1 more source

Understanding the proteomes using non‐proteomics approaches: Expanding the scope of PROTEOMICS [PDF]

PROTEOMICS, 2017
openaire   +2 more sources

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures. [PDF]

Cell
Shrestha HK, Sun H, Yarbro JM, Lee D, Liu D, Wang E, McReynolds M, Zhang N, Xie B, Yang S, Yu K, Poudel S, Li Y, Yuan ZF, Kong D, Wang M, Wang Z, Niu M, Wang H, Zaman M, Wang J, Vanderwall DR, Sun Y, Wu Z, Chen PC, Bai B, High AA, Faura J, Liu C, Bennett DA, Johnson ECB, Seyfried NT, Levey AI, Haroutunian V, Serrano GE, Beach TG, DeTure M, Kanekiyo T, Petersen RC, Bu G, McLean PJ, Dickson DW, Rademakers R, Yu G, Wang X, Zhang B, Peng J.   +46 more
europepmc   +1 more source