Results 171 to 180 of about 591,485 (302)

LC-MS proteomic characterization of TgCRND8 AD model mice brain tissue following the top-down approach

, 2016
LC-MS proteomic characterization of TgCRND8 AD model mice brain tissue following the top-down ...
DV Rossetti, S Scarpa, R Cavallaro, M Castagnola, C Desiderio, D Delfino, A Fuso, F Vincenzoni, F Iavarone, C Martelli, V Nicolia   +10 more
core  

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Social disconnection integrates genetic and proteomic risks in suicidal ideation and depression. [PDF]

Transl Psychiatry
Li S, Huang Z, Chen H, Chen X, Tang H, Ye Y, Zhu J, Wang S, Li P, Zhang S, Zhuang H, Liu W, Cai F, Song Z, Liu Y, Zhou J, Chen J.   +16 more
europepmc   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Explainable Plasma Proteomics-Based Machine Learning for Osteoporosis Diagnosis, Prognosis, and Protein Biomarker Discovery in the UK Biobank. [PDF]

FASEB J
Zhang W, Zhang W, Cheng H, Gong W, Kou Y, Jiang B.   +5 more
europepmc   +1 more source

Identification and proteomic profiling of exosomes in human urine.

Proceedings of the National Academy of Sciences of the United States of America, 2004
T. Pisitkun, Rong-Fong Shen, M. Knepper
semanticscholar   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

The proteomic architecture of clonal hematopoiesis: a systematic review of niche remodeling and multi-compartment predictors of malignant transformation. [PDF]

Front Med (Lausanne)
Husein JH, Khayata RM, Jahangir A, Mansour GK, Hajjar AW, Sajid MR.   +5 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source