Results 181 to 190 of about 599,323 (353)

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Proteomic profiling and molecular reclassification of high-grade serous ovarian cancer identifies prognostic subtypes and immunotherapy biomarkers. [PDF]

EBioMedicine
Tu M, Tang S, Zhang Q, Guo T, Cen Y, Xu X, Wu S, Chen X, Lu W, Ding C, Xu J.   +10 more
europepmc   +1 more source

Revealing Missing Human Protein Isoforms Based on Ab Initio Prediction, RNA-seq and Proteomics

, 2015
Zhiqiang Hu, Hamish S. Scott, Guangrong Qin, Guangyong Zheng, Xixia Chu, Lu Xie, David L. Adelson, Bergithe E Oftedal, Parvathy Venugopal, Milena Babic, Christopher N Hahn, Bing Zhang, Xiaojing Wang, Nan Li, Chaochun Wei   +14 more
openalex   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Machine learning integrated clinical-proteomics data identifies a 6-protein panel signature for atherosclerotic severity and enhanced patient stratification. [PDF]

Mol Biomed
Extremera-García MJ, Rojas-Torres M, Priego-Torres B, Beltrán-Camacho L, Eslava-Alcón S, Rodríguez-Martín F, Benítez-Camacho J, Ballesteros-Ribelles A, Del Val AM, Olsen J, Lozano-Loaiza E, González-García MÁ, Sanchez-Morillo D, Fernández-Vega A, Montaner J, Doiz E, Rodriguez-Piñero M, Durán-Ruiz MC.   +17 more
europepmc   +1 more source

Additional file 6: Table S5. of A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells

, 2016
Mandy J. Peffers, John J. Collins, John Loughlin, Carole J. Proctor, Peter Clegg   +4 more
openalex   +1 more source

Computational biology and structural proteomics [PDF]

, 2008
Amineni Umamaheswari, Dibyabhaba Pradhan, Vani Priyadrshini, G Subramnyam, Polamarasetty Aparoy, T Leela, Pallu Reddanna, Manju Bansal, Deepti Karandur, Nikhila Jayaprakash, Arvind Marathe, Agarwal Smita, Meruvu Sunitha, Kuhn Hartmun, Pallu Reddanna, T Prakash, C Ramakrishnan, D Dash, S Brahmachari, T Prakash, M Khandelwal, D Dasgupta, D Dash, S Brahmachari, R Schwyzer, Kim Lee, Sankararamakrishnan Prakash   +26 more
openalex   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Additional file 1: Table S1. of Investigation of proteome changes in osteoclastogenesis in low serum culture system using quantitative proteomics

, 2016
Qi Xiong, Lihai Zhang, Shaohua Zhan, Wei Ge, Peifu Tang   +4 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source