Results 271 to 280 of about 599,323 (353)

Identification of transcriptomic and proteomic biomarkers for TB and evaluation of point-of-care tests for diagnosis and treatment response

IL Manneh
openalex   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases. [PDF]

Neuron
Ali M, Timsina J, Xu Y, Chen Y, Gong K, Western D, Heo G, Liu M, Budde J, Pottier C, Schindler SE, Morris JC, Holtzman DM, Puerta R, Cano A, Boada M, Fernandez MV, Ruiz A, Aguilar M, Alvarez I, Pastor P, Perlmutter JS, Campbell MC, Kotzbauer PT, Oh HS, Wilson EN, Guen YL, Knight Alzheimer Disease Research Center (Knight-ADRC), Alzheimer Disease Neuroimaging Initiative (ADNI), Fundació ACE Alzheimer Center Barcelona (FACE), Barcelona-1, Stanford Alzheimer Disease Research Center (Stanford-ADRC), Global Neurodegeneration Proteomics Consortium (GNPC), Tarawneh R, Wyss-Coray T, Sung YJ, Ibanez L, Cruchaga C.   +37 more
europepmc   +1 more source

MassIVE MSV000100691 - Top-Down Proteomics in the Assessment of Kidney Donor Quality: a novel approach to increased organ utilization

Neil Kelleher
openalex   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Comparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes. [PDF]

Invest Ophthalmol Vis Sci
Luan Y, Tang J, Zhu T, Gu X, Chen Y, Wu P, Ding X, Yang L, Ye L, Zhang W, Zhuang A, Jia R, Chai P, Fan X.   +13 more
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Proteomic insights into the invasiveness and tumor progression of non-functioning pituitary adenomas: A scoping review. [PDF]

J Neuroendocrinol
Skoglund T, Köster L, Thorsell A, Ragnarsson O, Johannsson G, Hallén T.   +5 more
europepmc   +1 more source