Results 261 to 270 of about 591,485 (302)

Proteomic Stability and Ex Vivo Compatibility of a Processed Phospholipoproteic Secretome-Derived Formulation. [PDF]

Pharmaceutics
Gutiérrez-Sandoval R, Gutiérrez-Castro F, Muñoz-Godoy N, Rivadeneira I, Lagos A, Iturra J, Krakowiak F, Muñoz I, Toledo A.   +8 more
europepmc   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Proteomic Profile Differences in Immune-Related Diseases in Pediatric Patients Under Five Years Old: Asthma and IgE-Dependent Allergies-A Pilot Study. [PDF]

Int J Mol Sci
Rzetecka-Mańka N, Matysiak J, Matuszewska-Mach E, Sobkowiak P, Wojsyk-Banaszak I, Bręborowicz A, Borysewicz P, Klupczyńska-Gabryszak A, Matysiak J.   +8 more
europepmc   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Letter to the Editor regarding "Cysteine metabolism dysregulation promotes ferroptosis in osteoarthritis: Insights from multi-species bioinformatics and experimental validation". [PDF]

J Orthop Translat
Ni Y, Liu B.
europepmc   +1 more source

Plasma Proteomics in IgA Nephropathy: From Circulating Biomarkers to Molecular Endotypes. [PDF]

Cells
Delrue C, Marzocco S, Moresco RN, Speeckaert MM.   +3 more
europepmc   +1 more source

Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts. [PDF]

Nat Aging
Robinson O, Xiao H, Homann J, Viallon V, Ferrari P, Frank P, Huerta JM, Jiménez Zabala A, Kaaks R, Katzke VA, Kivimaki M, Langenberg C, Lau CE, Middleton L, Onland-Moret NC, Panico S, Prizment A, Ricceri F, Sánchez MJ, Smith-Byrne K, Verschuren WMM, Vermeulen R, Vineis P, Wang S, Wareham N, Lill CM, Riboli E, Gunter MJ.   +27 more
europepmc   +1 more source

Hepatic metabolic adaptation to endurance exercise: temporal and sex differences by multiomics integration and validation. [PDF]

Cell Commun Signal
Gao Y, Tu Z, Zhao Q, Peng J, Shu Y, Ren J, Deng X, Chen Y, Zhou Y, Zeng H, Chen B, Hao L.   +11 more
europepmc   +1 more source

Proteomic identification and histopathological validation of candidate biomarkers CA1, HBB, Torsin A, and <i>α</i>-Tubulin in gingivo-buccal oral squamous cell carcinoma. [PDF]

Front Med (Lausanne)
Shyamsundar V, Ravindran S, Krishnamurthy A, Venugopal DC, Madhavan Y, Sivagnanam A, Nair AM, Vimal S, Kesavan P, Senthil Subramaniyan N, Aravindha Babu N, Ramshankar V.   +11 more
europepmc   +1 more source