Results 91 to 100 of about 13,736,509 (195)

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Abrogation of B-Raf(V600E) induced senescence by FoxM1 expression

, 2019
B-Raf(V600E) oncogene mutation occurs in various cancers and is associated with tumor initiation. However, genetic modification of B-Raf(V600E) in cells induces MAPK activation and results in oncogene-induced senescence.
Kang, SY, Kim, JH, Kim, YH, Park, JH, Nam, GE, Yoon, JE, Choi, YW, Park, TJ   +7 more
core   +1 more source

The role of oncogenic Cbl mutants in Kit signaling and myeloid transformation [PDF]

, 2010
Acute myeloid leukemia (AML) is a hematopoietic cell disorder characterized by a block in differentiation and increased proliferation and survival of malignant blasts. Expansion of the malignant cell clone effects the normal production of blood cells and
Bandi, Srinivasa Rao
core  

Detailed Genetic Mapping of the A-raf Proto-oncogene on the Mouse X Chromosome

, 1991
The transcribed murine A-raf proto-oncogene has been localized to the proximal region of the mouse X chromosome, within the context of four other active genes in this region which together constitute a conserved linkage group between mouse and man.
Chapman, Verne M, Grant, Stephen G.
core   +1 more source

BRAF V600E Mutation in Odontogenic Keratocyst: A Systematic Review and Meta-Analysis

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To assess the frequency of the BRAF V600E mutation in odontogenic keratocyst, correlating the methods of evaluation and detection of the mutated protein.
Jéssica da Silva Cunha, Lucas Nascimento Ribeiro, Allan Vinícius Martins-de-Barros, Raisa Jordana Geraldine Severino-Lazo, Raíssa Soares dos Anjos, Renata de Albuquerque Cavalcanti Almeida, Mohammed N. Islam, Marianne de Vasconcelos Carvalho   +7 more
doaj  

Investigation of Oncogenic Gene Mutation and Associated Protein Expression in Ameloblastic Carcinoma

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to investigate gene mutations in ameloblastic carcinoma (AC) including BRAF, KRAS, and PIK3CA, along with associated protein expressions of BRAF V600E, p‐ERK1/2, and p‐mTOR, which represent activation of MAPK/ERK and PI3K/mTOR pathways, respectively.
Puangwan Lapthanasupkul, Jintana Pankam, Siribang‐on Piboonniyom Khovidhunkit, Prapapun Seneetuntigul, Nakarin Kitkumthorn   +4 more
wiley   +1 more source

Association of SIGLEC9 Expression with Cytokine Expression, Tumor Grading, KRAS, NRAS, BRAF, PIK3CA, AKT Gene Mutations, and MSI Status in Colorectal Cancer

Current Issues in Molecular Biology
SIGLEC9 (sialic acid-binding Ig-like lectin 9) is a molecule thought to have a significant influence on the immune properties of the colorectal cancer (CRC) tumor microenvironment (TME).
Błażej Ochman, Anna Kot, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Dominika Koszewska, Dorota Hudy, Monika Szrot, Jerzy Piecuch, Dariusz Waniczek, Zenon Czuba, Elżbieta Świętochowska   +11 more
doaj   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, Volume 159, Issue 7, Page 1715-1734, 1 October 2026.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1671-1685, October 2026.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Molecular and functional characterization of the interaction between c-Myc and the MCM helicase [PDF]

, 2006
The Myc genes (c-myc, n-myc, l-myc, s-myc) encode a family of protein that share structural an biological features and are conserved across all Metazoans.
Ruggiero, Luca
core   +1 more source