Results 121 to 130 of about 44,162 (208)

Synovial fibroblasts: key players in rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. The involvement of immune cells is a general hallmark of autoimmune-related disorders. In this regard,
Distler, O., Gay, R. E., Gay, S., Huber, L. C., Pap, T., Tarner, I.   +5 more
core  

Clinical evaluation and outcome in heart failure patients receiving chemotherapy with different anti‐cancer agents

ESC Heart Failure, Volume 12, Issue 3, Page 1965-1976, June 2025.
Abstract Background The optimal strategy for modern chemotherapy should be based on a comprehensive approach for cancer patients with cardiovascular diseases. Therefore, cardio‐oncology has received increasing attention owing to the cardiotoxic effects of anti‐cancer therapies.
Tomiko Sunaga, Takahiro Okada, Yoshitaka Iso, Mio Ebato, Tsutomu Toshida, Shuichi Nawata, Hiroshi Suzuki, Mari Kogo   +7 more
wiley   +1 more source

Protein Hypernetworks: a Logic Framework for Interaction Dependencies and Perturbation Effects in Protein Networks [PDF]

arXiv, 2011
Motivation: Protein interactions are fundamental building blocks of biochemical reaction systems underlying cellular functions. The complexity and functionality of such systems emerge not from the protein interactions themselves but from the dependencies between these interactions.
arxiv  

Real‐world experience of adjuvant immunotherapy for stages III–IV melanoma: A monocentric observational study

JEADV Clinical Practice, Volume 4, Issue 2, Page 425-439, June 2025.
Abstract Background Adjuvant immunotherapy (AIO) improved recurrence‐free survival (RFS) in patients with resected stages III–IV melanoma. Real‐world data, especially in elderly patients, as well as optimal management of patients who relpases, are still limited.
Manon Blaise, Eric Fontas, Barbara Seitz‐Polski, Laura Troin, Alexandra Picard, Perrine Rousset, Elodie Long‐Mira, Micheline Razzouk‐Cadet, Madleen Chassang, Thierry Passeron, Henri Montaudié   +10 more
wiley   +1 more source

Novel mechanisms of resistance to vemurafenib in melanoma – V600E B-Raf reversion and switching VEGF-A splice isoform expression [PDF]

, 2014
Targeting activating mutations in the proto-oncogene B-Raf, in melanoma, has led to increases in progression free survival. Treatment with vemurafenib, which inhibits the most common activating-mutated form of B-Raf (B-RafV600E), eventually results in ...
Bates, DO, Beazley Long, N, Gaston, Kevin, Harper, S J, Orlando, A   +4 more
core   +1 more source

Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages

Smart Medicine, Volume 4, Issue 2, June 2025.
This study reveals that polyamine metabolism significantly impacts thyroid carcinoma progression by modulating tumor‐associated macrophage phenotypes, influencing tumor growth and immune responses. ABSTRACT Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma ...
Haoran Ding, Lingling Xue, Shaoshi Zhu, Ziyu Wang, Huan Gui, Guang Zhang, Ning Tang, Haozhen Ren, Dayu Chen   +8 more
wiley   +1 more source

Accurate and efficient protein embedding using multi-teacher distillation learning [PDF]

arXiv
Motivation: Protein embedding, which represents proteins as numerical vectors, is a crucial step in various learning-based protein annotation/classification problems, including gene ontology prediction, protein-protein interaction prediction, and protein structure prediction.
arxiv  

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway

Aging Cell, Volume 24, Issue 6, June 2025.
Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar   +4 more
wiley   +1 more source

Protein Design with Dynamic Protein Vocabulary [PDF]

arXiv
Protein design is a fundamental challenge in biotechnology, aiming to design novel sequences with specific functions within the vast space of possible proteins. Recent advances in deep generative models have enabled function-based protein design from textual descriptions, yet struggle with structural plausibility.
arxiv  

An optimised Bcl‐3 inhibitor for melanoma treatment

British Journal of Pharmacology, Volume 182, Issue 11, Page 2426-2446, June 2025.
Abstract Background and Purpose Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma cells is the elevated expression of the proto‐oncogene Bcl‐3. This study aims to optimise, evaluate and characterise a second‐generation Bcl‐3 inhibitor, using
Karunakar Saamarthy, Renée Daams, Wondossen Sime, Cecilia Persson, Eduard Chygorin, Kristofer Ahlqvist, Susan Evans‐Axelsson, Daniel Strand, Ramin Massoumi   +8 more
wiley   +1 more source