EFFECT OF MELATONIN ON PANCREATIC AUTOPHAGY IN RATS WITH GESTATIONAL DIABETES MELLITUS AND THE MECHANISM [PDF]
精准医学杂志, 2023 Objective To investigate the effect of melatonin on pancreatic autophagy in rats with gestational diabetes mellitus (GDM) and the underlying mechanism.
ZHENG Qingqing, LI Chao, LI Yan, QIAO Binglong, MA Chunling
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PROTECTIVE EFFECT OF REMIMAZOLAM ON CEREBRAL NERVES IN A RAT MODEL OF CEREBRAL ISCHEMIA/REPERFUSION INJURY AND ITS MECHANISM [PDF]
精准医学杂志, 2023 Objective To investigate the protective effect of remimazolam on cerebral nerves in a rat model of cerebral ischemia/reperfusion injury and its mechanism.
DUAN Mei, LIU Jia, ZHANG Jing, SUN Xiaoli, WANG Shilei
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Notch: From fly wings to human hematological tumors [PDF]
Archive of Oncology, 2009 Notch history begins in 1919 with Thomas Hunt Morgan studies on fruit fly mutants. From then, this gene aroused lively interest in the scientific community since it is involved in a wide variety of processes, including morphogenesis, tissue homeostasis ...
Mirandola Leonardo +5 more
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Effect and mechanism of Juluo decoction combined with Ruhe powder in treatment of rat model of hyperplasia of mammary glands [PDF]
精准医学杂志Objective To investigate the effect and mechanism of Juluo Decoction combined with Ruhe Powder in the treatment of rat model of hyperplasia of mammary glands.
NIE Weihong, LIU Hongxi, SUN Guoxin, LIU Chengcong, ZOU Xiao
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Inhibition of Ultraviolet B-induced Apoptosis in Fibroblasts by Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Media via the Phosphatidylinositol-3-Kinase/Akt Pathway [PDF]
Iranian Journal of Medical SciencesBackground: Ultraviolet B (UVB) irradiation induces photoaging and apoptosis in various cell types. Inhibition of UVB-induced apoptotic pathways has been explored in different apoptotic cascades.
Ferry Sandra +6 more
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Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv +1 more source
Effect of minocycline on cognitive dysfunction in mice with intracerebral hemorrhage and its mechanism [PDF]
精准医学杂志Objective To investigate the effect of minocycline (Mcy) on cognitive dysfunction in mice with intracerebral hemorrhage (ICH) and its mechanism. Methods Male C57BL/6J mice were randomly divided into groups A, B, C, D, and E, with 20 mice in each group ...
LI Yangyang, FANG Jian, WANG Xiaoxue
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Binding of anisotropic curvature-inducing proteins onto membrane tubes [PDF]
Soft Matter 18, 3384-3394 (2022), 2022 Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered using mean-field theory including an orientation-dependent excluded volume.
arxiv +1 more source
Curvature sensing of curvature-inducing proteins with internal structure [PDF]
Phys. Rev. E 109, 024403 (2024), 2023 Many types of peripheral and transmembrane proteins can sense and generate membrane curvature. Laterally isotropic proteins and crescent proteins with twofold rotational symmetry, such as Bin/Amphiphysin/Rvs superfamily proteins, have been studied theoretically. However, proteins often have an asymmetric structure or a higher rotational symmetry.
arxiv +1 more source
In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]
ChemPhysChem 2020, 21, 377, 2019 We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
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