Results 101 to 110 of about 262,485 (201)

Comprehensive analysis and functional validation of key genes in bladder cancer progression

VIEW, EarlyView.
Bladder cancer is highly diverse between patients, making it difficult to accurately predict who will have aggressive disease and poor outcomes. In this study, we integrated single‐cell RNA sequencing with clinical survival data to identify a simple three‐gene signature (FAM3B, C10orf99, and VMP1) that stratifies patients into high‐ and low‐risk groups.
Xiaoning Cheng, Hongxia Zhao, Qian Li, Boyang Liu, Maoping Cai, Xinyi Wang, Jiancong Lie, Yuanyuan Qu, Jianwei Li, Chunlong Yang   +9 more
wiley   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, EarlyView.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells [PDF]

Mol Med Rep
Ding Q, Chen Y, Zhang Q, Guo Y, Huang Z, Dai L, Cao S.   +6 more
europepmc   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA. [PDF]

Mol Med Rep
Zhan S, Wang C, Yin F.
europepmc   +1 more source

KRAB Zinc‐Finger Protein ZNF205 Promotes Hepatocellular Carcinoma via p53 Pathway Repression

Cancer Science, EarlyView.
ZNF205 functions as a critical oncogenic regulator in hepatocellular carcinoma (HCC), where it interacts with p53 and functionally suppresses its transcriptional activity by competitively inhibiting p53 binding to target gene promoters. This p53 inactivation mechanism critically contributes to tumor progression in HCC. ABSTRACT The tumor suppressor p53
Xiaofen Huang, Yingchuan Yang, Yuan Ma, Wei Hao, Jingzhuo Jin, Yue Ding, Yiming Zhang, Xiuyuan Zhang, Xinli Li, Qin Song, Jiaqi Liu, Bingxin Liu, Yuanjun Zhai, Chunling Zhao, Jin Wu, Chunyan Tian   +15 more
wiley   +1 more source