Results 141 to 150 of about 85,248 (244)

OCT‐2 Is Associated With Pro‐Metastatic Epigenomic Properties of Triple‐Negative Breast Cancer Cells

Cancer Science, EarlyView.
The transcription factor OCT‐2 (encoded by POU2F2) is involved in the formation of super‐enhancers (SEs) in triple‐negative breast cancer (TNBC) cells. Overexpression of POU2F2 enhances the metastasis of TNBC cells in mice, and their expression is highly correlated to the poor prognosis of TNBC patients. ABSTRACT Triple‐negative breast cancer (TNBC) is
Kazuki Ogikubo, Jun Nishida, Kei Takahashi‐Yamashiro, Masato Morikawa, Shogo Ehata, Tetsuro Watabe, Kohei Miyazono, Daizo Koinuma   +7 more
wiley   +1 more source

Translational Advances in Oncogene and Tumor-Suppressor Gene Research. [PDF]

Cancers (Basel)
Stojchevski R, Sutanto EA, Sutanto R, Hadzi-Petrushev N, Mladenov M, Singh SR, Sinha JK, Ghosh S, Yarlagadda B, Singh KK, Verma P, Sengupta S, Bhaskar R, Avtanski D.   +13 more
europepmc   +1 more source

HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity

Cell Proliferation, EarlyView.
HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman, Aadil Javed, Azime Akçaöz Alasar, Bünyamin Akgül, Kemal Sami Korkmaz   +4 more
wiley   +1 more source

Crizotinib Inhibits Viability, Migration, and Invasion by Suppressing the <i>c-Met</i>/<i>PI3K</i>/<i>Akt</i> Pathway in the Three-Dimensional Bladder Cancer Spheroid Model. [PDF]

Curr Oncol
Song B, Kim D, Ho JN, Le VH, Lee S.
europepmc   +1 more source

Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
ABSTRACT Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA promotes cancer progression by influencing genomic instability, amplifying oncogenes, regulating ...
Jiajia Li, Peng Luo, Zhengrui Li, Qi Wang, Xufeng Huang, Keliang Wang, Ruo Wang, Runzhi Chen   +7 more
wiley   +1 more source

ATP6V0B promotes the tumorigenesis of bladder cancer by activating PAQR4/PI3K/AKT signaling. [PDF]

BMC Cancer
Wang X, Qu Y, Sun Y, Yang T, Wang W, Dou X, Jia Y.   +6 more
europepmc   +1 more source

Mechanistic Insights and Therapeutic Potentials of Ubiquitin‐Proteasome System in Non‐Small Cell Lung Cancer

Cell Proliferation, EarlyView.
Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou, Jiaxiong Tan, Pengpeng Zhang, Zhaokai Zhou, Lianmin Zhang, Zhenfa Zhang   +5 more
wiley   +1 more source

HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAF^V600E-mutant microsatellite stable colorectal cancer. [PDF]

J Immunother Cancer
Sun Z, Shi M, Xia J, Li X, Chen N, Wang H, Gao Z, Jia J, Yang P, Ji D, Gu J.   +10 more
europepmc   +1 more source

Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization

The FEBS Journal, EarlyView.
Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun, So Young Lee, Shin‐Young Park, Joong Sub Choi, Mee‐Sup Yoon, Joong‐Soo Han   +5 more
wiley   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source