Results 141 to 150 of about 260,711 (183)

GANT61 suppresses proliferation and induces apoptosis in ALK-Positive anaplastic large cell lymphoma via modulating the Hh-PIK3IP1-Akt signaling axis. [PDF]

Ann Hematol
Chen H, Gao J, Li C, Han Y, Liu S, Zhu X.   +5 more
europepmc   +1 more source

Functional Difference of MYC and MYCN in Combined Hepatocellular–Cholangiocarcinoma: Regulation of Differentiation by HNF1B

Cancer Science, Volume 117, Issue 2, Page 536-547, February 2026.
Combined hepatocellular–cholangiocarcinoma (cHCC‐CCA) is a tumor consisting of a mixture of hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CCA) components, but the mechanisms of development are poorly understood. The activation of Myc may be implicated in the formation of cHCC‐CCA and this work demonstrates for the first time that Myc ...
Masanori Goto, Masahiro Yamamoto, Hiroki Tanaka, Yumiko Fujii, Kumi Takasawa, Yuki Kamikokura, Masayo Kamikokura, Nobuyuki Kobayashi, Taro Murakami, Yuji Nishikawa, Akira Takasawa   +10 more
wiley   +1 more source

MYBL2 regulates the expression of CENPF in lung adenocarcinoma and promotes tumor development and metastasis through AKT pathway activation. [PDF]

Eur J Med Res
Liu Y, Yu F, Jiang J, Ma H.
europepmc   +1 more source

From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma

Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley   +1 more source

Emerging role of histone and non-histone lactylation in metabolic reprogramming of female-specific malignancies. [PDF]

World J Surg Oncol
Sun C, Hu D, Peng W, Cui Z, Lin Y.
europepmc   +1 more source

Microtubule Inhibitors Induce Cross‐Resistance to Osimertinib Through CaMKII Activation in EGFR‐Mutated NSCLC

Cancer Science, Volume 117, Issue 2, Page 418-428, February 2026.
Eighteen‐week treatment with microtubule inhibitors induces resistance to osimertinib in EGFR‐mutated NSCLC cells. Vinorelbine‐ and paclitaxel‐resistant cells showed activation of FZD7 and CaMKII and increased sensitivity to CaMKII inhibition, with additive or synergistic effects when combined with osimertinib.
Kento Kono, Ryosuke Tanino, Yukari Tsubata, Eshat Fahmida Haque, Takeshi Isobe, Tamio Okimoto   +5 more
wiley   +1 more source

MicroRNA-195-5p Targets MYB to Regulate Proliferation and Malignant Metastasis in Triple-Negative Breast Cancer via PI3K/AKT/mTOR Signaling. [PDF]

Breast J
Tang K, Bai S, Zhou Q, Liu S, Yin L, Tong Y, Long L, Ou L, Yin Q.   +8 more
europepmc   +1 more source

A YAP/TAZ–CDC6 Axis Initiates and Maintains Malignant Transformation

Cancer Science, Volume 117, Issue 2, Page 353-363, February 2026.
This study demonstrates that constitutive activation of YAP or TAZ is sufficient to induce and maintain malignant transformation in fibroblasts, identifying them as essential oncogenic drivers. Transcriptomic and functional analyses revealed CDC6 as a critical downstream effector of YAP/TAZ, with elevated expression linked to tumorigenesis across ...
David Nduru, Yudai Ohta, Akihiro Nita, Mayumi Niimura, Samson Ngurari, Toshiro Moroishi   +5 more
wiley   +1 more source

Retracted: Maternally-Expressed Gene 3 (MEG3)/miR-143-3p Regulates Injury to Periodontal Ligament Cells by Mediating the AKT/Inhibitory kB Kinase (IKK) Pathway. [PDF]

Med Sci Monit
Dong Y, Feng S, Dong F.
europepmc   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, Volume 117, Issue 2, Page 377-392, February 2026.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source