Results 31 to 40 of about 260,711 (183)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum. [PDF]

, 2011
In the present study we aimed to verify if the enhancement of glial cell line-derived neurotrophic factor (GDNF) production in mouse striatum following treatment with LY379268 may also induce in the nigrostriatal system a time-related activation of RET ...
BELLUARDO, Natale, DI LIBERTO, Valentina, MUDO', Giuseppa   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. [PDF]

, 2015
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers ...
Ab Hamid, Hasiah, Abd Hamid, Roslida, Ahmed, Nuzhat, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Ali, Abdul Manaf, Amedei, Amedeo, Andrade-Vieira, Rafaela, Azqueta, Amaya, Baglole, Carolyn J., Barclay, Barry J., Bay, Sarah N., Berg, Arthur, Bisson, William H., Blanco-Aparicio, Carmen, Brooks, Samira A., Brown, Dustin G., Brunborg, Gunnar, Calaf, Gloria M., Carlin, Danielle J., Carnero, Amancio, Carpenter, David O., Casey, Stephanie C., Castellino, Robert C., Chapellier, Marion, Charles, Amelia K., Chen, Tao, Chen, Zhenbang, Cheng, Qiang (Shawn), Chiaradonna, Ferdinando, Christopher, Joseph A., Cohen-Solal, Karine A., Colacci, Annamaria, Collins, Andrew R., Corsini, Emanuela, Cruickshanks, Nichola, Curran, Colleen S., D'Abronzo, Leandro S., Darbre, Philippa, Darroudi, Firouz, de Cerain Salsamendi, Adela Lopez, Decker, William K., Dent, Paul, Di Fiore, Riccardo, Dong, Chenfang, Dormoy, Valerian, Dornetshuber-Fleiss, Rita, Eltom, Sakina, Engstrom, Wilhelm, Eriksson, Staffan, Felsher, Dean W., Fernando Martinez-Leal, Juan, Forte, Stefano, Ghosh, Paramita M., Gilbertson, Michael, Goldberg, Gary S., Gonzalez, Laetitia, Gonzalez, Michael J., Goodson, William H, Guarnieri, Tiziana, Gulliver, Linda, Harris, Shelley A., Heneberg, Petr, Hsu, Chia-Wen, Hsu, Hsue-Yin, Hu, Zhiwei, Hultman, Tove, III, Jian, Le, Karamouzis, Michalis V., Khatami, Mahin, Kirsch-Volders, Micheline, Klaunig, James E., Kleinstreuer, Nicole, Koch, Daniel C., Kondoh, Hiroshi, Koppen, Gudrun, Koturbash, Igor, Kravchenko, Julia, Krishnakumar, P. K., Krishnan, Harini, Kuemmerle, Nancy B., Laconi, Ezio, Laird, Dale W., Langie, Sabine A. S., Lasfar, Ahmed, Lee, Tae-Jin, Leung, Po Sing, Leyns, Luc, Li, Lin, Lin, Liang-Tzung, Lleonart, Matilde, Lowe, Leroy, Luanpitpong, Sudjit, Luqmani, Yunus, Lyerly, H. Kim, Maguer-Satta, Veronique, Manjili, Masoud H., Marignani, Paola A., Marongiu, Fabio, Martin, Francis L., Massfelder, Thierry, McCawley, Lisa J., Mehta, Rekha, Memeo, Lorenzo, Miousse, Isabelle R., Mondello, Chiara, Moon, Eun-Yi, Moorwood, Kim, Nahta, Rita, Nangami, Gladys, Nangia-Makker, Pratima, Narayanan, Kannan Badri, Naus, Christian C., Ochieng, Josiah, Odero-Marah, Valerie, Ogunkua, Olugbemiga, Olsen, Ann-Karin, Ostrosky-Wegman, Patricia, Otsuki, Takemi, Palorini, Roberta, Papagerakis, Silvana, Park, Hyun Ho, Pavanello, Sofia, Ponce-Cusi, Richard, Prudhomme, Kalan R., Raju, Jayadev, Rathmell, W. Kimryn, Ratovitski, Edward, Robey, R. Brooks, Rojanasakul, Yon, Rojas, Emilio, Roman, Jesse, Romano, Maria Fiammetta, Romano, Simona, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Ryeom, Sandra, Sabbisetti, Venkata, Salem, Hosni K., Salzberg, Anna C., Sanderson, Thomas, Scovassi, A. Ivana, Singh, Neetu, Sinha, Ranjeet K., Sone, Hideko, Soucek, Laura, Sun, Jun, Thompson, Patricia, Vaccari, Monica, Vadgama, Pankaj, Valverde, Mahara, van Larebeke, Nik, Van Schooten, Frederik J., Vento, Renza, Vermeulen, Louis, Vondracek, Jan, Wade, Mark, Wagemaker, Gerard, Ward, Andrew, Weisz, Judith, Whitfield, Jonathan R., Williams, Graeme, Williams, Marc A., Wise, John Pierce, Sr., Wise, Sandra S., Wolf, Gregory T., Woodrick, Jordan, Xia, Menghang, Yasaei, Hemad, Yedjou, Clement, Zhang, Luoping, Zhou, Binhua P.   +173 more
core   +11 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Induction of MET Receptor Tyrosine Kinase Down-Regulation through Antibody-Mediated Receptor Clustering [PDF]

, 2019
The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound ...
Adam Dick, Fei Lu, Hong Sun, Hui Zhang, Wenjing Li   +4 more
core   +3 more sources