Results 31 to 40 of about 85,248 (244)

Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]

, 2005
Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Alzuherri, Aytekin, Barjesteh van Waalwijk van Doorn-Khosrovani, Bartholomew, Ben-Neriah, Bianchini, Carapeti, Carlesso, Daghistani, De Weer, Elrick, Fabbro, Fears, Gerhardt, Goyama, Hamilton, Henzan, Hoyt, Huang, Håkansson, Irvine, Jørgensen, Khanna-Gupta, Kilbey, Konopka, Kurzrock, Kustikova, Lin, Livak, Lugthart, Lugthart, Melo, Mitani, Morishita, Morishita, Morishita, Morishita, Nakamura, Nunoda, O'Hare, Ogawa, Paquette, Pendergast, Russell, Sellers, Skorski, Smith, Stevens-Kroef, Suzukawa, Valent, Wetzler, Wieser, Wimmer, Yuasa   +53 more
core   +1 more source

Length, Protein-Protein Interactions, and Complexity [PDF]

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Pathogenesis of endocrine thyroid cancer [PDF]

, 2015
This review aims to discuss the different genetic alterations that may come about and thus give rise to thyroid cancer. The importance of understanding the pathogenesis of this disease is in the use of these genetic alterations as prognostic markers and ...
Mallia, Nicola, Vassallo, Josanne
core  

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]

, 2012
Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized ...
A Clauset, A Ergün, A Subramanian, A-L Barabási, A-L Barabási, AH Wyllie, AJ Levine, B Vogelstein, B Weigelt, C Ortutay, C Secondini, CC Harris, CL Bailey, CL Chaffer, CL Smith, D Hanahan, D Hanahan, DH Jones, DJ Watts, DW Huang, E Cerami, E Eden, EK Sloan, F Emmert-Streib, G Bu, G Chen, Ganesh Bagler, GR Mundy, H Jeong, H Rangaswami, H Yu, H-S Wang, H-Y Chuang, J Lascorz, JA Blake, JE Talmadge, JL Dai, K Chu, K Eppert, K Matsumoto, KI Goh, KR Hess, L Freeman, M Cicek, M Smid, MA Yildirim, Matthias Dehmer, ME Higgins, MEJ Newman, MP Joy, MP Valta, MS Virk, NN Batada, P Jia, P Shannon, PF Jonsson, RS Taichman, S Dorogovtsev, S Maslov, S Mathivanan, S Peri, Shikha Vashisht, SR Rittling, SY Rhee, T Gene, T Koreckij, TA Guise, U Brandes, U Stelzl, W Chang, W Kozlow, WC Hahn, X Lu, X Zhang, XH-F Zhang, Y Kang, Y Mishina   +76 more
core   +4 more sources