Results 141 to 150 of about 106,346 (224)

Single‐cell sequencing reveals the role of IL‐33+ endothelial subsets in promoting early gastric cancer progression

iMeta, EarlyView.
A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...
Li Zhou, Mei Yang, Chao Deng, Manqiu Hu, Suhua Wu, Kewen Lai, Lili Zhang, Zhiji Chen, Qin Tang, Qingliang Wang, Lu Chen, Runmin Zha, Yuanyuan Chen, Yibo Tan, Song He, Zhihang Zhou   +15 more
wiley   +1 more source

Prognostic value of the expression of CD27 and CD117 in newly diagnosed multiple myeloma patients. [PDF]

BMC Immunol
Si X, Zhao J, Song Y, Fu W, Zhang R.
europepmc   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer. [PDF]

J Exp Clin Cancer Res
Li Z, Liu Z, Lin M, Pan H, Liu Y, Liu Y, Xie Y, Zhang J, Guan S, Li Y, Zhu M, Fang Y, Shen Z, Deng H.   +13 more
europepmc   +1 more source

A Systematic Evaluation of the Dosing Regimens for Approved Targeted Therapies and Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma From a Project OPTIMUS Perspective

The Journal of Clinical Pharmacology, EarlyView.
Abstract Targeted therapies and immune checkpoint inhibitors (ICIs) have significantly improved survival outcomes in metastatic renal cell carcinoma (mRCC) but are often associated with high rates of adverse events, leading to dose reductions or treatment discontinuation.
Zhiyuan Tan, Swantje Völler, Aymara Sancho‐Araiz, Catherijne A. J. Knibbe, Dirk Jan A. R. Moes   +4 more
wiley   +1 more source

Heterozygous deletion of exon 17 of the Kit gene impairs mouse spermatogenesis by attenuating MAPK-ERK signaling. [PDF]

Biol Res
Lin S, Yang M, Zhu W, Yang C, Chen Y, Cong P, Liu X, He Z.   +7 more
europepmc   +1 more source

Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients.
Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh   +10 more
wiley   +1 more source

ATP6V0B promotes the tumorigenesis of bladder cancer by activating PAQR4/PI3K/AKT signaling. [PDF]

BMC Cancer
Wang X, Qu Y, Sun Y, Yang T, Wang W, Dou X, Jia Y.   +6 more
europepmc   +1 more source

Differentiation of the mononuclear phagocyte system during mouse embryogenesis:the role of transcription factor PU.1 [PDF]

, 1999
Browne, C M, Henkel, G W, Hume, D A, Lichanska, A M, Maki, R A, McKercher, S R, Murphy, K M, Ostrowski, M C   +7 more
core  

Comparative LC‐MS Proteomics of Quinoa Grains: Evaluation of Bioactivity and Health Benefits by Combining In Silico Techniques With In Vitro Assays on Colorectal Adenocarcinoma Cells

Molecular Nutrition &Food Research, EarlyView.
Identifying health‐promoting molecules such as bioactive peptides in complex food mixtures is a major challenge. In this study, we investigated proteins and protein hydrolysates from four quinoa varieties to evaluate their potential anticancer effects on colorectal adenocarcinoma cells.
Alessandro Zaccarelli, Beatrice Mattina, Rocío Galindo‐Luján, Laura Pont, Fernando Benavente, Ilaria Zanotti, Lisa Elviri   +6 more
wiley   +1 more source