Results 151 to 160 of about 209,331 (178)

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, EarlyView.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Comprehensive transcriptomic characterization of two melanoma cell lines with acquired dual resistance to BRAF and MEK inhibitors. [PDF]

Sci Rep
Kujawa T, Simiczyjew A, Kot M, Gambin T, Nowak D, Kobiela T.   +5 more
europepmc   +1 more source

Nobiletin in cancer therapy: Emerging insights into multi-target mechanisms, overcoming drug resistance and therapeutic translation (Review). [PDF]

Oncol Lett
Zhang Y, Li Q, Yu W, He B, Peng J, Yao B.   +5 more
europepmc   +1 more source

Phenotypic alterations and PI3K-AKT pathway regulation in senescence of human tonsil mesenchymal stem cells. [PDF]

Stem Cell Res Ther
Qiu X, Lin Z, Sun Y, Zhao A, Chen X.
europepmc   +1 more source

Avapritinib for targeting KIT D816V-mutated acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplant with extramedullary and central nervous system involvement. [PDF]

Ann Hematol
Frigeni M, Algarotti A, Salmoiraghi S, Belotti C, Milani M, Pavoni C, Spinelli O, Gotuzzo I, Rambaldi A, Lussana F.   +9 more
europepmc   +1 more source

Copy Number Amplification and c-Myc Transcriptional Activation-Mediated RNA-Binding Protein MEX3A Promotes EGFR-TKI Resistance in Non-Small-Cell Lung Cancer. [PDF]

Thorac Cancer
Xiling S, Lin D, Jiali D, Chen Z, Ruohan H, Chang Z, Renhua G, Jun L.   +7 more
europepmc   +1 more source

Genomic Subtype Influences BH3 Mimetic Drug Sensitivity and Synergy with Cytotoxic Chemotherapeutics in T-cell Acute Lymphoblastic Leukemia. [PDF]

Clin Cancer Res
Yoshimura S, Li Y, Inoue S, Meyer CT, Yang X, Du G, Hsiao YC, Li Z, Yang W, Hu J, Andersen CL, Saygin C, Karol SE, Bernt KM, Yu J, Stock W, Teachey DT, Konopleva M, Yang JJ.   +18 more
europepmc   +1 more source

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Expression and Function of the c-kit Proto-Oncogene Protein in Mouse Sperm

The Journal of Urology, 1998
The presence and role of the c-kit protein were examined in mature sperm of the mouse. Monoclonal antibodies (mAbs) against the c-kit protein were used to perform immunohistochemical staining, electron microscopy studies, and Western blot analysis. The acrosomal region of both fixed and unfixed noncapacitated sperm stained with the antibodies.
H, Feng, J I, Sandlow, A, Sandra
openaire   +2 more sources

Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1997
The c-kit gene encodes a transmembrane receptor that has tyrosine kinase activity. c-kit plays a role in hematopoiesis, gametogenesis, and melanogenesis. c-kit is found in melanocytes, and there is evidence that expression is lost in melanoma. We studied 85 melanocytic lesions for c-kit by immunohistochemical techniques using a monoclonal antibody. The
K T, Montone, P, van Belle, R, Elenitsas, D E, Elder   +3 more
openaire   +1 more source

Proto oncogene protein C kit inhibitors

Reactions Weekly, 2020
openaire   +1 more source