Results 11 to 20 of about 209,331 (178)
No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides [PDF]
Anais Brasileiros de Dermatologia, 2018 : The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation.
David Aldo De Luca +3 more
doaj +1 more source
Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma [PDF]
Anais Brasileiros de Dermatologia, 2016 : Background: c-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter.
Ibrahim Sehitoglu +5 more
doaj +1 more source
Open Medicine, 2023 Ubiquitin-conjugating enzyme E2 C (UBE2C) plays a carcinogenic role in gastric cancer (GC); yet, its role in cisplatin (DDP) resistance in GC is enigmatic.
Long Jiegen +7 more
doaj +1 more source
Prospects of Chemotherapy for Gastrointestential Stromal Colon Tumours
Креативная хирургия и онкология, 2020 Gastrointetinal stromal tumours are the most common primary mesenchymal tumours of the gastrointestinal tract. According to statistical data, the annual incidence of this pathology in Russia comprises 13 patients per 1 million inhabitants, i.e.
A. R. Mukhamediyarov +3 more
doaj +1 more source
Review papers The role of KIT gene mutations in pathogenesis of pediatric mastocytosis
Przegląd Dermatologiczny, 2015 Mastocytosis is characterized by excessive proliferation and accumulation of mast cells in skin and/or other organs. Two forms of the disease, cutaneous and systemic mastocytosis, differ significantly in symptomatology and clinical course.
Joanna Dawicka +5 more
doaj +1 more source
Mast cells in oral lichen planus and oral lichenoid lesions related to dental amalgam contact
Brazilian Oral ResearchThe aim of this study was to analyze the expression of mast cell markers toluidine blue, c-kit, and tryptase and presence of mononuclear inflammatory cells in oral lichen planus (OLP) and oral lichenoid lesions related to dental amalgam.
Mariana Saturnino de NORONHA +6 more
doaj +1 more source
Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications
Brazilian Journal of OncologyRecognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of ...
Nildevande Firmino Lima-Jr +11 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source