Results 101 to 110 of about 19,940,452 (132)

miRNA profiling reveals that gga-let-7i/COL1A2 axis induces cell cycle arrest and triggers cellular senescence to accelerate ovarian aging in laying hens by suppressing the PI3K/AKT/MDM2 pathway. [PDF]

Poult Sci
Wei Y, Liao C, Wang Y, Cui C, Zhang Y, Li Z, Sun C, Zhu Q, Yin H, Han S.   +9 more
europepmc   +1 more source

Activity of PROTAC MDM2 degrader in primary leukemia cells and PDX models. [PDF]

Leukemia
Kandarpa M, Peterson LF, Potu H, Ramappan M, Liu Y, Polk A, Wang S, Talpaz M.   +7 more
europepmc   +1 more source

Dysfunction of the Autophagy System and MDM2-p53 Axis Leads to the Accumulation of Amyloidogenic Proteins in Angelman Syndrome Models. [PDF]

Int J Mol Sci
Martins de Almeida JF, Contestabile M, Tonazzini I, De Cesari C, Baroncelli L, Martini C, Daniele S.   +6 more
europepmc   +1 more source

Transcriptomic characterization of mesenchymal and skin tissues in <i>Cervus elaphusxanthopygus</i> antler and identification of growth-related candidate genes. [PDF]

PeerJ
Bi X, Liu B, Li B, Zhao M, Tian H, Chen J.   +5 more
europepmc   +1 more source

Analysis of a large osteosarcoma sequencing data set elucidates patterns of genomic alterations. [PDF]

Cancer
Bousquet HG, Kuang Z, Vega LL, Ceca E, Schiantarelli J, Honecker J, Hiemenz MC, Forrest SJ, Janeway KA.   +8 more
europepmc   +1 more source

Enolase 2-mediated lactylation-dependent disruption of the GNL3-MDM2-p53 axis in age-related osteoarthritis. [PDF]

Cell Mol Biol Lett
Hua F, Nan J, Wu R, Zhang B, Liu Q, Ma T, Zhang Z, Hu Y, Xie J, Yang Y.   +9 more
europepmc   +1 more source

PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells. [PDF]

Cells
Kim Y, Kim JW, Choi J, Kim J, Park S, Choi W, An H, Kim J, Kim M, Choi S, Lim J, Lee HI, Lee S.   +12 more
europepmc   +1 more source

MDM2 Drives Proteasome Inhibitor Resistance and Represents a TP53-Independent Therapeutic Vulnerability in Multiple Myeloma. [PDF]

Cells
Labrador M, Cozzubbo S, Porro M, Cumerlato M, Bandini C, Mereu E, Paradzik T, Donati B, Manicardi V, Ronchetti D, D'Agostino M, Larocca A, Gay F, Bruno B, Ciarrocchi A, Chatr-Aryamontri A, Neri A, Morelli E, Piva R.   +18 more
europepmc   +1 more source

Role of mutant p53 and autophagy on precancerous lesions of gastric cancer progression: A review. [PDF]

Medicine (Baltimore)
Wang Q, Wu Y, Wang W.
europepmc   +1 more source

Efficacy of Wee1 G2 Checkpoint Kinase and Mouse Double Minute 2 Homolog Inhibitors in Gastrointestinal Stromal Tumors Determined by p53 Status. [PDF]

Oncol Res
Chen CP, Tang YJ, Cai YY, Pan YR, Yeh CN, Huang WK, Lo CH, Hsiao YT, Shih HJ, Wu CE.   +9 more
europepmc   +1 more source